Chapter 17, Problem 3
What features of eukaryotes provide additional opportunities for the regulation of gene expression compared to bacteria?
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In this chapter, we focused on how eukaryotic gene expression is regulated posttranscriptionally. At the same time, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter:
How do we know that double-stranded RNA molecules can control gene expression?
Write a short essay describing how an mRNA may be regulated in three different ways by specific cis-elements and RBPs.
List three types of alternative splicing patterns and how they lead to the production of different protein isoforms.
Consider the CT/CGRP example of alternative splicing shown in Figure 18.3. Which different types of alternative splicing patterns are represented?
Explain how the use of alternative promoters and alternative polyadenylation signals produces mRNAs with different 5' and 3' ends.
Explain how a tissue-specific RNA-binding protein can lead to tissue-specific alternative splicing via splicing enhancers or splicing silencers.