Chapter 17, Problem 4
Consider the CT/CGRP example of alternative splicing shown in Figure 18.3. Which different types of alternative splicing patterns are represented?
Video transcript
Write a short essay describing how an mRNA may be regulated in three different ways by specific cis-elements and RBPs.
List three types of alternative splicing patterns and how they lead to the production of different protein isoforms.
Explain how the use of alternative promoters and alternative polyadenylation signals produces mRNAs with different 5' and 3' ends.
Explain how a tissue-specific RNA-binding protein can lead to tissue-specific alternative splicing via splicing enhancers or splicing silencers.
The regulation of mRNA decay relies heavily upon deadenylases and decapping enzymes. Explain how these classes of enzymes are critical to initiating mRNA decay.