Incorrectly spliced RNAs often lead to human pathologies. Scientists have examined cancer cells for splice-specific changes and found that many of the changes disrupt tumor-suppressor gene function [Xu and Lee (2003). Nucl. Acids Res. 31:5635–5643]. In general, what would be the effects of splicing changes on these RNAs and the function of tumor-suppressor gene function? How might loss of splicing specificity be associated with cancer?

Video transcript

Hi, everyone. Let's look at our next problem. If a non coding region known as an intron is not removed during the blank process in MRN A translation will result in the formation of altered or nonfunctional proteins. So that process of removing noncoding RN A is the process of choice C splicing that removes the introns and then joins together the coding regions, coding regions or exxons to form the mature MRN A that will be translated into a functional protein. If those enrons aren't removed, then the translation process, as our question says, will result in the formation of altered or nonfunctional proteins due to the disruption of those coding exons. Now let's look at our other answer choices to understand why they're not correct. Obviously, we can eliminate choice D none of the above. Since we have that correct answer of spicing uh choice A tailing refers to the addition of a poly A tail to the three prime end of the MRN A. So that's not the correct answer, not describing what we want. So let's cross that off. And then choice B capping is the addition of a modified guanine base to the five prime end compare to three prime end to perform that five prime cap that's gonna protect the MRN A from degradation, but it's not what we're looking for. So it's not our correct answer here. So again, if a non coding region known as an Enron is not removed during the choice C splicing process in MRN A translation will result in the formation of alter or nonfunctional proteins. See you in the next video.