A glycine residue is in position 210 of the tryptophan synthetase enzyme of wild-type E. coli. If the codon specifying glycine is GGA, how many single-base substitutions will result in an amino acid substitution at position 210? What are they? How many will result if the wild-type codon is GGU?

Video transcript

Hello everyone here We have a question that says blank results in an amino acid substitution because the coding is changed and the new code on codes for a different amino acid. We have a single base deletion. A single base deletion is when a nucleotide is removed from a code on. This can lead to changes in the amino acid sequence of the protein. But it doesn't necessarily result in an amino acid substitution because the coding is not changed. So A. Is incorrect. Be single base insertion. As the name suggests, these are mutations in which an extra nucleotide is added to a code on. So B. Is incorrect. C single base substitution. This is right because single base substitution result in an amino acid substitution because the code on has changed and the new code on codes for a different amino acid. So our answer here is C. Single base substitution. Thank you for watching. Bye.