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Ch. 13 - The Genetic Code and Transcription
All textbooksKlug 12th EditionCh. 13 - The Genetic Code and TranscriptionProblem 33
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Chapter 13, Problem 33

Isoginkgetin is a cell-permeable chemical isolated from the Ginkgo biloba tree that binds to and inhibits snRNPs.

What types of problems would you anticipate in cells treated with isoginkgetin?

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Hello everyone and welcome to today's video. So cancer immunotherapy is one of the most promising treatments for malignancy. Recently. The eye surgeon getting derivative I. P. Two should increase PTP derived antigens presentation in cancer cells in vitro and in person to more growth in vivo determine what is true about eye surgeon getting in the following statements. So let's go over each of these statements so that we may solve this problem. Let's begin by statement. A surgeon getting is proven to be psycho toxic to both normal and cancer cells. Well this is actually a correct statement. It does have an effect against cancer cells but it also becomes side a toxic it becomes toxic to normal cells as you're going to damage them as well because of this. We're not going to cancel this out. Then we have eyes surgeon getting on its own can be used to treat malignancies. Well partially we could use it to treat malignancies but remember that it is going to be side a toxic to normal cells because of this we cannot use eye surgeon getting on its own. We have to use some type of derivative that comes from it that is that retains its anti tumor or its anti cancer cell properties while not being silent toxic to normal cells. And this is usually what is used instead of eye surgeon getting on its own because of this. This is going to be an incorrect answer choice and we're going to cancel it out then C and D. Are both A and B. And none of the above. So neither one of these is going to be to either. The only correct answer choice here is going to be answer choice. I really hope this video helped you and how to see you on the next one.
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Textbook Question

RNAi is currently being tested as a therapeutic tool for genetic diseases and other conditions. Consider the following: cystic fibrosis caused by loss of function of the CFTR gene, HIV infection, and cancer caused by hyperactivity of a growth factor receptor. Which of these may be treatable by RNAi, and which not? Explain your reasoning.

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Textbook Question

Explain how the expression of a single gene can be quickly, efficiently, and specifically shut down at the transcriptional, posttranscriptional, and posttranslational stages through the coordinated expression of a transcriptional repressor, an miRNA, and a ubiquitin ligase.

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Textbook Question

Recent observations indicate that alternative splicing is a common way for eukaryotes to expand their repertoire of gene functions. Studies indicate that approximately 50 percent of human genes exhibit alternative splicing and approximately 15 percent of disease-causing mutations involve aberrant alternative splicing. Different tissues show remarkably different frequencies of alternative splicing, with the brain accounting for approximately 18 percent of such events [Xu et al. (2002). Nucl. Acids Res. 30:3754–3766].

Why might some tissues engage in more alternative splicing than others?

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Textbook Question

Isoginkgetin is a cell-permeable chemical isolated from the Ginkgo biloba tree that binds to and inhibits snRNPs. Would this be most problematic for E. coli cells, yeast cells, or human cells? Why?

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