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Ch. 10 - DNA Structure and Analysis
Chapter 10, Problem 17

How do covalent bonds differ from hydrogen bonds? Define base complementarity.

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1
Step 1: Understand that covalent bonds are strong chemical bonds formed by the sharing of electron pairs between atoms. These bonds are responsible for holding together the atoms within a molecule, such as the sugar-phosphate backbone of DNA.
Step 2: Recognize that hydrogen bonds are weaker interactions compared to covalent bonds. They occur when a hydrogen atom covalently bonded to an electronegative atom, like oxygen or nitrogen, experiences an attraction to another electronegative atom nearby.
Step 3: Note that in the context of DNA, hydrogen bonds are crucial for the formation of the double helix structure. They occur between complementary nitrogenous bases on opposite strands, stabilizing the DNA structure.
Step 4: Define base complementarity as the specific pairing of nitrogenous bases in DNA, where adenine (A) pairs with thymine (T) through two hydrogen bonds, and cytosine (C) pairs with guanine (G) through three hydrogen bonds.
Step 5: Understand that base complementarity is essential for DNA replication and transcription, ensuring that genetic information is accurately copied and expressed.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Covalent Bonds

Covalent bonds are strong chemical bonds formed when two atoms share one or more pairs of electrons. This sharing allows each atom to attain a full outer shell of electrons, leading to greater stability. Covalent bonds are typically found in organic molecules, such as DNA and proteins, and are essential for the structure and function of these biomolecules.
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Hydrogen Bonds

Hydrogen bonds are weaker interactions that occur between a hydrogen atom covalently bonded to an electronegative atom and another electronegative atom. These bonds are crucial for the properties of water and the structure of biological macromolecules, such as the double helix of DNA, where they help stabilize the strands by forming between complementary base pairs.
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Base Complementarity

Base complementarity refers to the specific pairing of nitrogenous bases in nucleic acids, where adenine pairs with thymine (or uracil in RNA) and cytosine pairs with guanine. This principle is fundamental to the structure of DNA, ensuring accurate replication and transcription processes. The hydrogen bonds between complementary bases facilitate the double helix formation and maintain genetic fidelity.
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