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Ch.17 - Aqueous Ionic Equilibrium
Chapter 17, Problem 55b

If the volume of blood in a normal adult is 5.0 L, what mass of HCl can be neutralized by the buffering system in blood before the pH falls below 7.0 (which would result in death)?

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1
Identify the buffering system in blood, which is primarily the bicarbonate buffer system: \( \text{HCO}_3^- + \text{H}^+ \rightleftharpoons \text{H}_2\text{CO}_3 \).
Determine the concentration of bicarbonate ions (\( \text{HCO}_3^- \)) in blood, which is typically around 24 mM.
Calculate the total moles of \( \text{HCO}_3^- \) in 5.0 L of blood using the formula: \( \text{moles} = \text{concentration} \times \text{volume} \).
Use the stoichiometry of the reaction to find the moles of \( \text{HCl} \) that can be neutralized, noting that 1 mole of \( \text{HCO}_3^- \) neutralizes 1 mole of \( \text{HCl} \).
Convert the moles of \( \text{HCl} \) to mass using the molar mass of \( \text{HCl} \) (36.46 g/mol) with the formula: \( \text{mass} = \text{moles} \times \text{molar mass} \).