Chapter 18, Problem 5c
Compare and contrast the items in each pair: (c) general transcription factors and sigma.
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What is alternative splicing? a. phosphorylation that leads to different types of post-translational regulation b. mRNA processing that leads to different combinations of exons being spliced together c. folding that leads to proteins with alternative conformations d. the outcome of regulatory proteins that leads to changes in the life span of an mRNA
Compare and contrast the items in each pair: (a) enhancers and the E. coli CAP binding site
Compare and contrast the items in each pair: (b) promoter-proximal elements and the operator of the lac operon
Predict how a mutation that caused continuous production of active p53 would affect the cell.
In the follow-up work to the experiment shown in Figure 19.6, the researchers used a technique that allowed them to see if two DNA sequences are in close physical proximity (association). They applied this method to examine how often an enhancer and the core promoter of the Hnf4a regulatory gene were near each other. A logical prediction is that compared with rats born to mothers fed a healthy diet, the Hnf4a gene in rats born to mothers fed a protein-poor diet would a. show no difference in how often the promoter and enhancer associated. b. never show any promoter–enhancer association. c. show a lower frequency of promoter–enhancer association. d. show a higher frequency of promoter–enhancer association.
One hypothesis for differences between humans and chimpanzees involves differences in gene regulation. A study using RNA-seq showed that the overall patterns of gene expression were similar in the liver and blood of the two species, but the expression patterns were strikingly different in the brain. How do these results relate to the hypothesis?