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Ch. 18 - Control of Gene Expression in Bacteria
Chapter 17, Problem 4

A regulon is a set of genes controlled by a. one type of regulator of transcription. b. two or more different alternative sigma proteins. c. many different types of promoters. d. glucose.

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Identify the key term: A regulon is a collection of genes or operons that are regulated as a unit, typically under the control of the same regulatory protein.
Understand the options: Analyze each option to see which best fits the definition of a regulon.
Option a suggests that a regulon is controlled by one type of regulator of transcription, which aligns with the definition of a regulon being regulated by a common regulatory mechanism.
Option b, c, and d introduce multiple regulators, different promoters, or a specific substance (glucose) which do not strictly adhere to the concept of a regulon being controlled by a single type of regulatory protein.
Conclude that the correct answer is a. one type of regulator of transcription, as it best fits the definition of a regulon.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Regulon

A regulon is a collection of genes that are regulated together by a common regulatory protein, often in response to specific environmental conditions. This allows for coordinated expression of genes that contribute to a particular biological function or response, such as metabolism or stress adaptation.

Transcription Regulation

Transcription regulation involves mechanisms that control the transcription of genes, determining when and how much of a gene product is made. This can occur through various factors, including transcription factors, which can either promote or inhibit the binding of RNA polymerase to DNA, thus influencing gene expression.
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Sigma Factors

Sigma factors are proteins that bind to RNA polymerase and direct it to specific promoters, initiating transcription. Different sigma factors can recognize different sets of promoters, allowing bacteria to adapt their gene expression in response to environmental changes, which is essential for survival and growth.
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Related Practice
Textbook Question

Why are the genes involved in lactose metabolism considered to be an operon? a. They occupy adjacent locations on the E. coli chromosome. b. They have a similar function. c. They are all required for normal cell function. d. They are all controlled by the same promoter.

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Textbook Question

In the lac operon, the repressor inhibits transcription when a. the repressor is bound to the inducer. b. the repressor is not bound to the inducer. c. the repressor is bound to glucose. d. the repressor is not bound to the operator.

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Textbook Question

Activators bind to regulatory sequences in ________ and to ________ polymerase.

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Textbook Question

Evaluate these statements about regulation of the lac operon. Select True or False for each statement. T/F The lac operon is transcribed at the highest rate when extracellular glucose and lactose are abundant. T/F The repressor protein is bound to DNA of the operator when lactose is present. T/F A mutation in the operator is likely to prevent transcription of the lac operon under any condition. T/F A mutation that alters the catabolite activator protein is predicted to alter the regulation of many different operons.

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Textbook Question

Predict what would happen to regulation of the lac operon if the lacI gene were moved 50,000 nucleotides upstream of its normal location.

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Textbook Question

Explain why it makes sense for the lexA regulatory gene of the SOS regulon to be expressed constitutively.

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