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Cancer
Chapter 6, Problem 4

The centromere is a region at which                   . a. sister chromatids are attached to each other; b. metaphase chromosomes align; c. the tips of chromosomes are found; d. the nucleus is located

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1
Identify the function of the centromere in cell division.
Understand that the centromere is crucial for the correct distribution of chromosomes during cell division.
Recognize that sister chromatids are the identical copies formed by the DNA replication of a chromosome, joined together by the common centromere.
Analyze the options given in the question to determine which one correctly describes the role of the centromere.
Select the option that states the centromere is where sister chromatids are attached to each other.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Centromere Function

The centromere is a specialized region of a chromosome that plays a crucial role during cell division. It is the point where sister chromatids are held together, ensuring proper segregation into daughter cells. The centromere is essential for the formation of the kinetochore, a protein structure that facilitates the attachment of spindle fibers during mitosis and meiosis.
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Sister Chromatids

Sister chromatids are identical copies of a single chromosome that are formed during DNA replication. Each chromatid is joined at the centromere, and they remain attached until they are separated during cell division. Understanding the relationship between sister chromatids and the centromere is vital for grasping how genetic material is accurately distributed to daughter cells.
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Metaphase Alignment

During metaphase, chromosomes align at the cell's equatorial plane, known as the metaphase plate. This alignment is critical for ensuring that each daughter cell receives an equal and accurate set of chromosomes. The centromere's role in this process is to anchor the chromosomes to the spindle apparatus, facilitating their proper separation in the subsequent anaphase.
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