The Na+-Glucose symporter transports the two molecules into the cell, while the Na+-K+ ATPase uses ATP to transport Na+ ions out of the cell. What would be the result of a mutation leading to a nonfunctional Na+-Glucose symporter?

Decreased activity of the Na + -K + ATPase.

The Na + -Glucose symporter transports the two molecules into the cell, while the Na + -K + ATPase uses ATP to transport Na+ ions out of the cell. What would be the result of a mutation leading to a nonfunctional Na + -Glucose symporter?

Alright. So this practice problem says the sodium glucose importer transports the 2 molecules, of course, sodium ions and glucose, into the cell. While the sodium potassium ATPase uses ATP to transport sodium ions out of the cell and of course potassium ions into the cell. And then the problem asks, what would be the result of a mutation leading to a non functional sodium glucose symporter? And we've got these 5 potential answer options down below. Now the problem does a great job of reminding us that the sodium glucose symporter's job is to transport the 2 molecules into the cell. But of course if we have a non functional sodium glucose importer, it means that it will not be able to do its job, and so it will not transport the 2 molecules into the cell. And so therefore, what we would expect is that a non functional sodium glucose importer would lead to less sodium ions and less glucose inside of the cell. And so, a nonfunctional sodium glucose importer, we would expect to lead to less sodium and less glucose inside of the cell since it won't be able to do its job of transporting these 2 molecules into the cell. And so what we need to realize here is that the sodium potassium ATPase relies heavily on sodium ions, specifically intracellular sodium ions since it takes those intracellular sodium ions and pumps them to the outside of the cell. And so having less sodium ions on the inside of the cell is going to correspond with decreased activity of the sodium potassium ATPase. And so that's really what we would expect here is that, the, having less sodium inside the cell is going to lead to decreased activity of the sodium potassium ATPase. And so when we take a look at option a here, it says increased levels of intracellular potassium. And, of course, we know that the sodium potassium ATPase pumps potassium into the cell. And so if there are increased levels of intracellular potassium, that suggests that there is increased activity of the sodium potassium ATPase. But, of course, we know that there should be decreased activity, not increased activity of the Sodium Potassium ATPase activity. And so because a suggests increase of activity not a decrease of activity of the Sodium Potassium ATPase, what we can do is eliminate option a. Now option b here says, increase levels of intracellular glucose, but of course here we just mentioned that there's going to be less glucose inside of the cell as a result of the non functional sodium glucose importer. And so, it will not have increased levels of intracellular glucose. And so, looking down at option c here, notice that it actually says decrease activity of the sodium potassium ATPase. And notice that matches up pretty much perfectly with what we expected here, and so we do expect that there should be decreased activity of the Sodium Potassium ATPase since there will be less sodium inside of the cell for the Sodium Potassium ATPase to work with. And so we can go ahead and indicate that c here is actually the correct answer to this practice problem. Now just for, thoroughness here, checking option d, it says over activation of the Sodium Potassium ATPase, which is the complete opposite of option c and that's why it's incorrect. And then option e here says, increased levels of ATP, but of course, we know that glucose is going to be a main source of energy to acquire ATP. And so if there's less glucose inside of the cell, then if anything we would expect there to be less, ATP as a result of that, not increased levels of ATP. And so that is not gonna be the best answer for this problem. And so again, option c here is the correct answer and that concludes this practice problem. So I'll see you guys in our next video.

The Na+-Glucose symporter transports the two molecules into the c...

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The Na⁺-Glucose symporter transports the two molecules into the cell, while the Na⁺-K⁺ ATPase uses ATP to transport Na+ ions out of the cell. What would be the result of a mutation leading to a nonfunctional Na⁺-Glucose symporter?