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Ch. 4 Histology
Chapter 4, Problem 4.4a

Fill in the blanks: Tight junctions make the spaces between cells____, whereas desmosomes increase the____of a tissue.

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Identify the function of tight junctions in cellular structures.
Understand that tight junctions create a seal between cells, preventing the passage of molecules and ions through the space between cells.
Recognize that the term to fill in the first blank should relate to the impermeability or sealing function of tight junctions.
Identify the function of desmosomes in cellular structures.
Understand that desmosomes provide mechanical strength and stability to tissues by anchoring cells together, so the term to fill in the second blank should relate to the strength or cohesion of the tissue.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Tight Junctions

Tight junctions are specialized connections between adjacent epithelial cells that create a barrier to prevent the passage of molecules and ions through the space between cells. They are crucial for maintaining the integrity of tissues by controlling permeability and ensuring that substances must pass through the cells rather than between them.
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Desmosomes

Desmosomes are intercellular junctions that provide strong adhesion between cells, particularly in tissues that experience significant mechanical stress, such as skin and cardiac muscle. They consist of protein complexes that anchor to the cytoskeleton, enhancing the structural integrity and resilience of the tissue.
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Cell Junctions

Cell junctions are specialized structures that facilitate communication and adhesion between cells in a tissue. They play a vital role in maintaining tissue architecture and function, with different types, such as tight junctions, desmosomes, and gap junctions, serving distinct purposes in regulating permeability, mechanical strength, and intercellular communication.
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