Mr. Gupta has been diagnosed with nephrotic syndrome, which is characterized by the loss of plasma proteins such as albumin into the urine. What impact will this have on his colloid osmotic pressure? How will this affect the net filtration pressure in his capillary beds? What effect will this likely cause?

Video transcript

Hey, everyone. Let's take a look at this question together which of the following statements about the impacts of nephrotic syndrome on the capillary beds within the glomeruli is true. Is it answer choice? A, the permeability in the capillaries decreases. Answer choice B, it will inhibit the passage of all protein molecules. Answer choice C, it will result in the leakage of elastin into the urine or answer choice D it will lead to water retention in the tissues. Let's work this problem out together to try to figure out which of the following answer choices contains a statement about the impacts of nephrotic syndrome on the capillary beds within the glomeruli is true. So, in order to solve this question, we have to recall what we have learned about nephrotic sy and its impact on the capillary beds within the glomeruli. And we know that nephrotic syndrome is characterized by increased permeability of the glomerular filtration barrier. And when we say increased permeability of the glomerular filtration barrier, we are saying that larger molecules can pass more freely and due to that increased permeability of the ameer filtration barrier, it leads to the loss of proteins, particularly albumin in the urine. And that loss of albumin is important since albumin helps maintain oncotic pressure. And that loss of albumin results in having less albumin, which in turn leads to low oncotic pressure. And as a result of low oncotic pressure, there is increased water retention in the tissues, which means that nephrotic syndrome ultimately leads to increased water retention in the tissues. No answer. Choice. D is the correct answer. As the impact of nephrotic syndrome on the capillary beds within the glomeruli is that it will lead to water retention in the tissues and all other answer choices are incorrect. I hope you found this video to be helpful. Thank you and goodbye.