A patient, Dr. Young, has both asthma and high blood pressure. Her physician prescribed the drug propranolol to treat her hypertension; this drug blocks all types of β-adrenergic receptors. She also takes the drug albuterol for asthma, which activates β2 receptors on bronchial smooth muscle. Will the pairing of these two drugs cause problems for Dr. Young? Explain.
Ch. 14 The Autonomous Nervous System and Homeostasis
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Erin C. Amerman 2nd Edition
Ch. 14 The Autonomous Nervous System and Homeostasis
Problem 14.3a
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Chapter 14, Problem 14.3a
Mr. Chevalier has been diagnosed with Horner syndrome, which is caused by dysfunction of the sympathetic neurons in the superior cervical ganglion that innervate structures of the head, face, and neck. What symptoms is Mr. Chevalier likely to face due to his disease? Explain.
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Understand that Horner syndrome is a result of disruption in the sympathetic nervous system, specifically affecting the superior cervical ganglion.
Recognize that the sympathetic nervous system is responsible for the 'fight or flight' response, which includes pupil dilation, eyelid elevation, and sweating.
Identify that due to the dysfunction in the sympathetic neurons, Mr. Chevalier may experience ptosis (drooping of the upper eyelid) because the muscles that elevate the eyelid are not receiving proper sympathetic stimulation.
Consider that miosis (constricted pupil) may occur because the dilator muscle of the pupil is not being activated by the sympathetic nervous system.
Acknowledge that anhidrosis (lack of sweating) on the affected side of the face may also be a symptom, as the sweat glands are not receiving sympathetic signals.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Horner Syndrome
Horner syndrome is a neurological condition resulting from disruption of sympathetic nerve pathways, particularly affecting the eye and surrounding structures. It is characterized by a triad of symptoms: ptosis (drooping of the upper eyelid), miosis (constricted pupil), and anhidrosis (lack of sweating) on the affected side of the face. Understanding this syndrome is crucial for identifying the specific symptoms Mr. Chevalier may experience.
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Sympathetic Nervous System
The sympathetic nervous system is part of the autonomic nervous system responsible for the body's 'fight or flight' response. It regulates involuntary functions such as heart rate, blood pressure, and sweating. Dysfunction in this system, particularly in the superior cervical ganglion, can lead to the symptoms seen in Horner syndrome, highlighting the importance of sympathetic pathways in facial and ocular function.
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Superior Cervical Ganglion
The superior cervical ganglion is the largest of the sympathetic ganglia and is located in the neck. It plays a critical role in innervating structures in the head and neck, including the eyes, salivary glands, and sweat glands. Damage or dysfunction in this ganglion can lead to the hallmark symptoms of Horner syndrome, making it essential to understand its function and location in relation to Mr. Chevalier's condition.
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Related Practice
Textbook Question
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Textbook Question
Sympathetic preganglionic neurons synapse:
a. directly on target cells.
b. on skeletal muscle fibers.
c. on sympathetic chain or collateral ganglia.
d. on vagal ganglia.
243
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Textbook Question
Describe all the changes initiated by the parasympathetic nervous system that will take place when you finish the race. How will these changes maintain homeostasis?
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Textbook Question
Differentiate between adrenergic and cholinergic receptors.
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Textbook Question
Which neurotransmitter(s) is/are used by sympathetic postganglionic neurons?
a. Epinephrine
b. Norepinephrine
c. Acetylcholine
d. Both a and b
e. All of the above
270
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Textbook Question
Explain what happens when sympathetic neurons stimulate the adrenal medulla. What purpose does this serve?
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