Huntington's disease is characterized by a loss of normal inhibition mediated by the basal nuclei. Predict the symptoms you are likely to see with this disease.

Video transcript

Hi, everyone. Let's take a look at this practice problem together in Huntington's disease, several parts of the brain are affected, choose which parts are included. The answer options are a globus pallidus, B, thalamus C, subthalamic nucleus, D, Substantia, Nigra. E both options B and C and F. All of the above recall that Huntington's disease is a genetic disorder and it is caused by the gradual degeneration of the basal nuclei. Symptoms of Huntington's disease include uncoordinated and jerky movements, mental changes and memory loss. So, what are the basal nuclei recall that the basal nuclei are clusters of neuron cell bodies and these clusters lie deep below the cerebral cortex. The basal nuclei regulate voluntary motor movements and they have roles in emotions, behavior and executive functions. Parts of the basal nuclei are some of the answer options including the globus pallidus, the subthalamic nucleus and the substantia nigra. So options. AC and D are all areas of the brain affected by Huntington's. In addition, option B, the thalamus is also affected. The basal nuclei sends signals to the nuclei in the thalamus that can then project the information to other areas. So the thalamus communicates with the basal nuclei. So it is also affected in Huntington's disease. Therefore, the correct answer is f all of the above. All right. Everyone. I hope you found this helpful and I'll see you soon for the next practice problem.