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Ch. 10 Muscle Tissue and Physiology
Chapter 10, Problem 10.5a

What is the basic mechanism of contraction at the level of myofilaments?

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1
Identify the two main types of myofilaments involved in muscle contraction: actin (thin filaments) and myosin (thick filaments).
Understand the role of calcium ions (Ca²⁺) in muscle contraction. Calcium ions bind to troponin, causing a conformational change that moves tropomyosin away from the myosin-binding sites on actin filaments.
Recognize the importance of ATP in the contraction cycle. ATP binds to the myosin head, causing it to detach from the actin filament. The hydrolysis of ATP to ADP and inorganic phosphate (Pi) provides the energy for the myosin head to return to its 'cocked' position.
Describe the cross-bridge cycle: The myosin head binds to the exposed binding sites on actin, forming a cross-bridge. The release of ADP and Pi from the myosin head triggers the power stroke, pulling the actin filament toward the center of the sarcomere.
Explain the role of the sarcoplasmic reticulum in muscle relaxation. When the muscle is no longer stimulated, calcium ions are actively transported back into the sarcoplasmic reticulum, allowing tropomyosin to cover the binding sites on actin, leading to muscle relaxation.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Myofilaments

Myofilaments are the contractile proteins found within muscle fibers, primarily composed of actin (thin filaments) and myosin (thick filaments). These proteins interact during muscle contraction, facilitating the shortening of muscle fibers. Understanding their structure and function is crucial for grasping how muscles generate force.
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Sliding Filament Theory

The Sliding Filament Theory explains how muscle contraction occurs at the molecular level. According to this theory, during contraction, myosin heads attach to actin filaments and pull them inward, causing the filaments to slide past each other. This process shortens the sarcomere, the basic unit of muscle contraction, leading to overall muscle shortening.
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Calcium Ions and Troponin

Calcium ions play a critical role in muscle contraction by binding to troponin, a regulatory protein on the actin filament. This binding causes a conformational change that moves tropomyosin away from the myosin-binding sites on actin, allowing myosin heads to attach and initiate contraction. This mechanism is essential for the regulation of muscle contraction in response to neural signals.
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Related Practice
Textbook Question

Ms. Sanchez was in a motorcycle accident in which she lost the use of her right upper limb muscles due to significant nerve damage. However, when an electrode is inserted into her muscles, they are able to contract. Explain specifically why nerve damage caused her to lose the use of her muscles. Why can they still respond to stimulation from an electrode?

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Textbook Question

Match the following terms with the correct definition.      


____Z-disc     

____Sarcomere     

____A band     

____H zone     

____I band     

____M line


a. The dark band containing the entire length of the thick filament

b. The band of proteins in the middle of the H zone

c. The boundary between sarcomeres

d. The functional unit of contraction

e. The middle region of the A band containing only thick filaments

f. The light band containing only thin filaments

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Textbook Question

Mr. Nasheed has cerebral palsy and suffers severe skeletal muscle spasms as a result of his condition. He is prescribed the drug dantrolene, which prevents the release of Ca2+ from the SR. Explain how this will treat his muscle spasms.

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Textbook Question

Jesse is a 2-year-old boy who presents with difficulty in walking and poor control of movements. When the doctor examines Jesse, she notices that when his muscles contract, they are very slow to relax and remain contracted well after the movement has been performed. She sends a sample of his tissue for genetic analysis, and the lab reports a genetic defect that causes the pumps in the SR to operate much more slowly than normal. How does a defect in DNA lead to a malfunctioning protein? How does this finding explain Jesse's symptoms? (Connects to Chapter 3)

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Textbook Question

Paola is a 3-year-old girl with a disease that reduces the ability of her mitochondria to generate ATP. Explain the specific effects of this disease on the ability of Paola's muscles to function properly. What other tissues and organs are likely to be especially affected by her disease, and why? (Connects to ​Chapter 3​)

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Textbook Question

Order the following events of excitation and excitation-contraction coupling. Put 1 by the first event, 2 by the second, and so on.


          ​​​​

____The motor end plate generates an end-plate potential.          ​​​​

____The action potential spreads along the T-tubules, SR Ca2+ channels are pulled open, and Ca2+ flood the cytosol.          ​​​​

____Acetylcholine binds to receptors on the motor end plate, and ligand-gated ion channels open.          ​​​​

____Ca2+ bind troponin, which allows tropomyosin to move away from the actin active site, initiating a contraction cycle.          ​​​​

____The action potential propagates through the sarcolemma and dives deeply into the cell along the T-tubules.

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