Patients with Chédiak-Higashi syndrome suffer from various types of cancer. These patients are most likely lacking which of the following?

a. Treg cells

b. TH1 cells

c. B cells

d. NK cells

e. TH2 cells

Video transcript

Welcome back everyone. Let's look at our next question. It says which immune system cells are stimulated by the humoral immune system to participate in A DC C A B cells. BT cells C and K cells or D all of the above. Well, to be able to evaluate this, we need to remember what is A DC C and that is antibody dependent cell mediated cytotoxicity. And this system occurs when a target cell has a bunch of antibodies bind to it. It's usually a cell that's too large to be engulfed by something like a macrophage and different types of immune system cells bind those antibodies and begin to attack the target cell. So we see that it's antibody dependent. The target cell is identified by all the antibodies bound to it. And then cell mediated cto cytotoxicity, these immune system cells then come bind to those antibodies and begin to kill the target cell. So when we think of cytotoxicity, we kind of have two classes that usually come to mind right away. And that's cytotoxic T cells and NK cells otherwise known as natural killer cells. So right there in the names, we have help to remember what they are cytotoxic T cells and natural killer cells. And in the case of this A DC C system, it is the NK cells that participate in the system. They're one of the types of cell that bind to these antibodies. So choice C is going to be our answer. Although we do need to consider our other choices since we know we can have more than one correct answer. So we have B cells and T cells. Well, the B cells are not one of the types of cells that attacks the other cells. B cells of course, are usually associated with the creation of antibodies. So, B cells are involved in this humoral immune response. But earlier in the process, they are the cells that produce the antibodies that are going to bind to that target cell. So they are not correct, which makes all of the above incorrect. And then T cells also are involved in the humoral immune system but not part of this ad or not part of the cytotoxic aspect of ABC CT cells help to regulate antibody production, working in coordinating with the B cells. There are also those cytotoxic T cells as we mentioned, but they have a different process or by which they go through to destroy cells. They don't go through the ABC C process. They are activated by recognizing peptides presented by MH C class one complexes. So choice BT cells are not participating in A DC C. So again, the immune system cells that participate in A DC C after being stimulated by the humoral immune system is choice cnk cells. See you in the next video.