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Ch. 12 - Adaptive Immunity
Chapter 11, Problem 12.7a

Which of the following does not generate long-term immunological memory? Select all that apply. (NCLEX/HESI/TEAS)
a. Antivenom
b. Antitoxins
c. Vaccinations
d. Breast-feeding
e. Antigens

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1
Understand the concept of immunological memory: It is the ability of the immune system to respond more rapidly and effectively to pathogens that have been encountered previously.
Identify which options involve passive immunity: Passive immunity involves the transfer of antibodies from one individual to another and does not generate long-term immunological memory.
Analyze each option: a) Antivenom, b) Antitoxins, c) Vaccinations, d) Breast-feeding, e) Antigens.
Determine which options provide passive immunity: Antivenom and antitoxins provide immediate protection by introducing antibodies, but they do not stimulate the immune system to produce its own antibodies.
Consider the role of vaccinations and antigens: Vaccinations introduce antigens to stimulate the immune system to develop memory, while antigens are substances that can trigger an immune response.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Immunological Memory

Immunological memory refers to the ability of the immune system to remember past infections and respond more effectively upon re-exposure to the same pathogen. This is primarily achieved through the formation of memory B and T cells after an initial exposure, which allows for a quicker and stronger immune response in future encounters.
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Passive Immunity

Passive immunity is a form of immunity acquired by the transfer of antibodies from one individual to another, providing immediate but temporary protection. Examples include antivenom and antitoxins, which offer short-term immunity without the body developing its own memory cells, thus not contributing to long-term immunological memory.
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Active Immunity

Active immunity occurs when the immune system is exposed to a pathogen or its components, leading to the production of antibodies and memory cells. This can happen naturally through infection or artificially through vaccinations, which stimulate the immune system to create a lasting defense against specific pathogens.
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