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Ch. 3 - Cell Structure and Function
Chapter 3, Problem 3.11a

A Gram-negative cell is moving uric acid across the cytoplasmic membrane against its chemical gradient. Which of the following statements is true?


a. The exterior of the cell is probably electrically negative compared to the interior of the cell.
b. The acid probably moves by a passive means such as facilitated diffusion.
c. The acid moves by an active process such as active transport.
d. The movement of the acid requires phagocytosis.

Verified step by step guidance
1
Identify the type of cell: The problem states that it is a Gram-negative cell, which is important for understanding the cell structure and transport mechanisms.
Understand the movement of uric acid: The problem specifies that uric acid is moving against its chemical gradient, which implies that energy is required for this process.
Consider the types of transport: Passive transport (like facilitated diffusion) does not require energy and moves substances down their gradient, while active transport requires energy to move substances against their gradient.
Evaluate the options: Option (b) suggests passive means, which is unlikely since the movement is against the gradient. Option (c) suggests active transport, which aligns with the requirement of moving against the gradient.
Conclude the most likely process: Since the movement is against the gradient and requires energy, active transport (option c) is the most plausible explanation.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Gram-negative Bacteria

Gram-negative bacteria are characterized by their thin peptidoglycan layer and an outer membrane containing lipopolysaccharides. This structure affects their permeability and the way they interact with their environment, including the transport of substances across the cytoplasmic membrane. Understanding this is crucial for analyzing how substances like uric acid are moved in and out of these cells.
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Active Transport

Active transport is a cellular process that moves molecules against their concentration gradient, requiring energy, typically in the form of ATP. This is essential for maintaining cellular homeostasis and allowing cells to uptake necessary nutrients, such as uric acid, even when they are in lower concentrations outside the cell. Recognizing this process helps in determining the correct mechanism of transport in the given question.
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Chemical Gradient

A chemical gradient refers to the difference in concentration of a substance across a membrane. In the context of uric acid transport, moving it against its chemical gradient implies that the concentration of uric acid is higher inside the cell than outside. This concept is fundamental to understanding why active transport is necessary for the movement of uric acid in this scenario.
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