Monoclonal antibodies __________.

a. are produced by hybridomas
b. are secreted by clone cells
c. can be used for passive immunization
d. all of the above

Question

Monoclonal antibodies __________.

a. are produced by hybridomas

b. are secreted by clone cells

c. can be used for passive immunization

d. all of the above

Accepted Answer

Hello, everyone. And welcome back. Let's look at the next question in the context of immunology. Which statement is true about monoclonal antibodies. A they are generated from multiple types of immune cells. B they originate from a single cell type and have uniform specificity. C they cannot be used in medical treatments or D each batch is derived from different hybrid cells. So to answer this question, we want to think about what is meant by monoclonal antibodies. And the answer is these are lab created proteins that act like our natural antibodies. So they bind to specific antigens. And how are they lab created? Well, they created as we recall are B cells produce antibodies and every antibody produced is specific for binding to a single antigen. But to generate large amounts, sufficient amounts of, of, of these in the lab, scientists fuse B cells for a specific antigen of interest, put specific antigen in parentheses with cancer cells which seems very weird. But think about what they do is specifically myeloma cells. Well, that means they're immortal. So you take the B cell that has the characteristic of making antibodies to a specific antigen and fuse it with a cell that can keep on dividing and replicating indefinitely, it doesn't die. So you essentially make a hybrid cell line and the hybrid cell line is called a hybridoma. So with that in mind, let's evaluate our statements looking for the true statement about these monoclonal antibodies choice. A, they are generated from multiple types of immune cells. Well, we see that they're generated, they're made with a hybrid cell line, but it's not multiple types of immune cells, they're generated from only a single B cell. And that is so all of the cell, all of the antibodies made will have the same antigen specificity. So choice A is incorrect. Well, now we get to choice B, they originate from a single cell type and have uniform specificity. So there we go. Just based on what we just discussed when talking about A, you can see that B is going to be our true statement about monoclonal antibodies to be thorough. Let's take a look at the other two answer. Choices. Choice C says they cannot be used in medical treatments. Well, this is definitely not true. The whole reason you're making them in a lab is because they're useful and they're used wisely and widely in medical treatments because you can design essentially antibodies to whatever you want to target. So they're used in cancer treatment and used for treatment of autoimmune diseases. So choice C not our answer. And then finally choice D each batch is derived from different hybrid cells. And this is also incorrect again. And we've got monoclonal antibodies right, in the name that tells us that they come from the same cell line. So the same hybridoma and this is of course, so batches will be consistent, which is always important whenever you're talking about any sort of, you know, lab production of some sort of, you know, something that you are producing in large quantities, you want every batch to be consistent with every other batch. So d also not our answer choice. Our answer about which statement is true about monoclonal antibodies is choice B they originate from a single cell type and have uniform specificity. See you in the next video.

Monoclonal antibodies __________.

a. are produced by hybridomas
b. are secreted by clone cells
c. can be used for passive immunization
d. all of the above

Verified Solution

Key Concepts