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Ch.12 Food as Fuel–An Overview of Metabolism
Chapter 8, Problem 12.25

In terms of high-energy molecules, what is the net output for one molecule of glucose undergoing glycolysis?

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Understand that glycolysis is the process of breaking down one molecule of glucose (C_6H_{12}O_6) into two molecules of pyruvate.
Recognize that during glycolysis, a net gain of ATP and NADH molecules occurs.
Identify that glycolysis consumes 2 ATP molecules in the initial steps but produces 4 ATP molecules in the later steps, resulting in a net gain of ATP.
Note that glycolysis also produces 2 NADH molecules as high-energy electron carriers.
Summarize the net output of glycolysis as 2 ATP and 2 NADH molecules per glucose molecule.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Glycolysis

Glycolysis is a metabolic pathway that converts glucose into pyruvate, producing energy in the form of ATP and NADH. This process occurs in the cytoplasm of cells and consists of ten enzymatic reactions. It is the first step in cellular respiration and is anaerobic, meaning it does not require oxygen.
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Net ATP Yield

The net ATP yield from glycolysis refers to the total amount of ATP produced minus the ATP consumed during the process. For one molecule of glucose, glycolysis typically yields a net gain of 2 ATP molecules. This is crucial for understanding the energy balance in cellular metabolism.
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NADH Production

During glycolysis, two molecules of NADH are produced for each molecule of glucose. NADH serves as an electron carrier, playing a vital role in the electron transport chain, where it contributes to further ATP production. The generation of NADH is essential for cellular respiration and energy metabolism.
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