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Ch. 7 - Sex Determination and Sex Chromosomes
Chapter 7, Problem 11

What is the basis for homology among chromosomes?

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Understand that homologous chromosomes are pairs of chromosomes in a diploid organism that have the same structure and gene sequence.
Recognize that each homologous chromosome in a pair comes from one parent, meaning one is maternal and the other is paternal.
Identify that the basis for homology among chromosomes is the similarity in their DNA sequences, which allows them to pair up during meiosis.
Note that homologous chromosomes have the same genes at the same loci, but they may have different alleles, which are variations of a gene.
Consider that the pairing of homologous chromosomes during meiosis is crucial for genetic recombination and the proper segregation of chromosomes into gametes.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Chromosomal Homology

Chromosomal homology refers to the similarity between chromosomes that share a common ancestry. Homologous chromosomes have the same genes at the same loci, but may carry different alleles. This concept is crucial for understanding genetic variation and inheritance patterns, as homologous chromosomes pair during meiosis, facilitating genetic recombination.
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Gene Structure and Function

Genes are segments of DNA that encode for proteins or functional RNA molecules. Understanding gene structure, including exons and introns, is essential for grasping how genetic information is organized within homologous chromosomes. The function of genes influences traits and can vary between homologous chromosomes due to allelic differences.
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Meiosis and Genetic Recombination

Meiosis is a specialized form of cell division that reduces the chromosome number by half, resulting in gametes. During meiosis, homologous chromosomes undergo recombination, where segments of DNA are exchanged. This process increases genetic diversity and is fundamental to the inheritance of traits, making it a key aspect of understanding chromosomal homology.
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Related Practice
Textbook Question
What specific observations (evidence) support the conclusions about sex determination in Drosophila and humans?
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Textbook Question

An insect species is discovered in which the heterogametic sex is unknown. An X-linked recessive mutation for reduced wing (rw) is discovered. Contrast the F₁ and F₂ generations from a cross between a female with reduced wings and a male with normal-sized wings when the male is the heterogametic sex.

283
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Textbook Question
An insect species is discovered in which the heterogametic sex is unknown. An X-linked recessive mutation for reduced wing (rw) is discovered. Contrast the F₁ and F₂ generations from a cross between a female with reduced wings and a male with normal-sized wings when the female is the heterogametic sex.
386
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Textbook Question

Consider the case where a mutation occurs that disrupts translation in a single human mitochondrion found in the oocyte participating in fertilization. What is the likely impact of this mutation on the offspring arising from this oocyte?

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Textbook Question
It has been suggested that any male-determining genes contained on the Y chromosome in humans cannot be located in the limited region that synapses with the X chromosome during meiosis. What might be the outcome if such genes were located in this region?
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Textbook Question
Predict the potential effect of the Lyon hypothesis on the retina of a human female heterozygous for the X-linked red-green color blindness trait.
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