Ch. 5 - Chromosome Mapping in Eukaryotes
Chapter 5, Problem 15
Another cross in Drosophila involved the recessive, X-linked genes yellow (y), white (w), and cut (ct). A yellow-bodied, white-eyed female with normal wings was crossed to a male whose eyes and body were normal but whose wings were cut. The F₁ females were wild type for all three traits, while the F₁ males expressed the yellow-body and white-eye traits. The cross was carried to an F₂ progeny, and only male offspring were tallied. On the basis of the data shown here, a genetic map was constructed. Phenotype Male Offspring y + ct 9 + w + 6 y w ct 90 + + + 95 + + ct 424 y w + 376 y + + 0 + w ct 0 Could the F₂ female offspring be used to construct the map? Why or why not?
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Textbook Question
In Drosophila, a cross was made between females—all expressing the three X-linked recessive traits scute bristles (sc), sable body (s), and vermilion eyes (v)—and wild-type males. In the F₁, all females were wild type, while all males expressed all three mutant traits. The cross was carried to the F₂ generation, and 1000 offspring were counted, with the results shown in the following table.
Phenotype Offspring
sc s v 314
+ + + 280
+ s v 150
sc + + 156
sc + v 46
+ s + 30
sc s + 10
+ + v 14
No determination of sex was made in the data.
Calculate the coefficient of coincidence. Does it represent positive or negative interference?
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Textbook Question
Another cross in Drosophila involved the recessive, X-linked genes yellow (y), white (w), and cut (ct). A yellow-bodied, white-eyed female with normal wings was crossed to a male whose eyes and body were normal but whose wings were cut. The F₁ females were wild type for all three traits, while the F₁ males expressed the yellow-body and white-eye traits. The cross was carried to an F₂ progeny, and only male offspring were tallied. On the basis of the data shown here, a genetic map was constructed.
Phenotype Male Offspring
y + ct 9
+ w + 6
y w ct 90
+ + + 95
+ + ct 424
y w + 376
y + + 0
+ w ct 0
Diagram the genotypes of the F₁ parents.
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Textbook Question
Another cross in Drosophila involved the recessive, X-linked genes yellow (y), white (w), and cut (ct). A yellow-bodied, white-eyed female with normal wings was crossed to a male whose eyes and body were normal but whose wings were cut. The F₁ females were wild type for all three traits, while the F₁ males expressed the yellow-body and white-eye traits. The cross was carried to an F₂ progeny, and only male offspring were tallied. On the basis of the data shown here, a genetic map was constructed.
Phenotype Male Offspring
y + ct 9
+ w + 6
y w ct 90
+ + + 95
+ + ct 424
y w + 376
y + + 0
+ w ct 0
Construct a map, assuming that white is at locus 1.5 on the X chromosome.
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Textbook Question
Another cross in Drosophila involved the recessive, X-linked genes yellow (y), white (w), and cut (ct). A yellow-bodied, white-eyed female with normal wings was crossed to a male whose eyes and body were normal but whose wings were cut. The F₁ females were wild type for all three traits, while the F₁ males expressed the yellow-body and white-eye traits. The cross was carried to an F₂ progeny, and only male offspring were tallied. On the basis of the data shown here, a genetic map was constructed.
Phenotype Male Offspring
y + ct 9
+ w + 6
y w ct 90
+ + + 95
+ + ct 424
y w + 376
y + + 0
+ w ct 0
Were any double-crossover offspring expected?
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Textbook Question
In Drosophila, Dichaete (D) is a mutation on chromosome III with a dominant effect on wing shape. It is lethal when homozygous. The genes ebony body (e) and pink eye (p) are recessive mutations on chromosome III. Flies from a Dichaete stock were crossed to homozygous ebony, pink flies, and the F₁ progeny, with a Dichaete phenotype, were backcrossed to the ebony, pink homozygotes. Using the results of this backcross shown in the table,
Phenotype Number
Dichaete 401
ebony, pink 389
Dichaete, ebony 84
pink 96
Dichaete, pink 2
ebony 3
Dichaete, ebony, pink 12
wild type 13
What is the sequence and interlocus distance between these three genes?
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Textbook Question
In Drosophila, Dichaete (D) is a mutation on chromosome III with a dominant effect on wing shape. It is lethal when homozygous. The genes ebony body (e) and pink eye (p) are recessive mutations on chromosome III. Flies from a Dichaete stock were crossed to homozygous ebony, pink flies, and the F₁ progeny, with a Dichaete phenotype, were backcrossed to the ebony, pink homozygotes. Using the results of this backcross shown in the table,
Phenotype Number
Dichaete 401
ebony, pink 389
Dichaete, ebony 84
pink 96
Dichaete, pink 2
ebony 3
Dichaete, ebony, pink 12
wild type 13
Diagram this cross, showing the genotypes of the parents and offspring of both crosses.
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