Researchers have identified some tumors that have no recurrent mutations or deletions in known oncogenes or tumor-suppressor genes and no detectable epigenetic alterations. However, these tumors often have large chromosomal deletions. What are some possible explanations that could account for the genetic causes behind these tumors?

Video transcript

Hello everyone here's our next question. Which of the following does not contribute to tumor development. So let's look over our answer choices, remembering we're looking for the one that is not a part of tumor development. Choice A says activation of tumor suppressor gene. Um Well if you have a tumor suppressor gene and you've activated it um that's obviously going to help suppress the growth of tumors. So would not contribute to tumor development. So this is going to be our answer here. Since this suppresses tumor growth. That tumor suppressor gene regulates cell growth and maintains healthy growth and spread of cells. So we're going to highlight choice A as our answer here. But let's just look through other choices to be thorough. Choice B says gene duplications and gene duplications definitely do contribute to tumor development. Specifically the amplification of the ah M. d. m. two gene can prevent The binding of the p. tumor suppressor. And as we saw above and we talked about tumor suppressors, that's something that prevents the tumor suppressor from acting definitely contributes to development. So Choice B. Is not our answer here. Then. Choice C. Says an increase in gene copy numbers and that can also contribute to tumors. Um Specifically example of that is a high number so high number of E. R. B. B. two gene copies um is associated with breast cancer. So this is another factor that can contribute to development. And so not our answer. And then finally, choice D mutations and genes necessary for DNA repair again, if your cells cannot repair DNA damage that damage DNA quite often is a factor and tumor development. That's why things like UV light are carcinogens because they cause DNA damage. So Choice D also not our answer. So again, which of the following does not contribute to tumor development. Choice, a activation of tumor suppressor gene. See you in the next video.