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Ch. 24 - Cancer Genetics
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All textbooksKlug 12th EditionCh. 24 - Cancer GeneticsProblem 15

Chapter 23, Problem 15

How do translocations such as the Philadelphia chromosome contribute to cancer?

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Hi everyone. Let's take a look at this practice problem together. The philadelphia chromosome, also known as the philadelphia translocation is a unique genetic aberration in chromosome blank of leukemia cancer cells. The genetic aberration is an abnormality. So we're looking at an abnormal chromosome so which chromosome is abnormal in leukemia cancer cells and is called the philadelphia chromosome. Now the name philadelphia translocation describes the an abnormality which is a translocation and a translocation is a genetic change where a piece of chromosome breaks off and attaches to a different chromosome. Now the philadelphia chromosome is a reciprocal translocation And what is a reciprocal translocation? Well, that is where one part of a chromosome is exchanged with another. So in the case of the Philadelphia chromosome, a piece of chromosome 22 is exchanged with chromosome nine and this leads to chromosome 22 being abnormally small and can lead to leukemia. So the answer is D. 22, chromosome 22 is the Philadelphia chromosome. Alright, everyone, I hope you found this helpful and I'll see you soon for the next practice problem.
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