Describe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote cell-cycle arrest and apoptosis. Given that TP53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene?

Video transcript

Everyone. Let's take a look at this question Together, blank represent the majority of p 53 mutations which result in the production of entirely mutant P 53 proteins. So let's recall what we've learned about p 53 mutations. To try to figure out what type of mutation represents the majority of those P 53 mutations. So we know that a P 53 mutation involves a mutation that changes and amino acid in that P 53 gene. So, looking at the types of mutations listed below which one best represents that change in the amino acid of a gene causing the proteins function to be impaired. Well, we know that answer. Choice C. A. Mis sense mutation is a mutation that deuces a different amino acid because it alters one of the base pairs substituting it to alter that genetic code so that it produces a different amino acid, which means that answer Choice C. A. Mis sense mutation is a type of mutation that best represents the majority of p 50 three mutations because it produces entirely mutant p 53 proteins, since it produces that different amino acid in those p 53 genes. So, answer Choice C. Is the correct answer. I hope you found this video to be helpful. Thank you and goodbye