Explain differences between whole-genome sequencing (WGS) and whole-exome sequencing (WES), and describe advantages and disadvantages of each approach for identifying disease-causing mutations in a genome. Which approach was used for the Human Genome Project?

Video transcript

Hey, everyone. Let's take a look at this question together which of the following options best describes the difference between whole genome sequencing and whole XOM sequencing. So let's recall what we've learned about what whole genome sequencing is. And compared to whole Xom sequencing to figure out which of the following options best describes the difference between the two. So we know that whole genome sequencing includes coding and non coding regions in its sequencing. And we know that the whole X um sequencing only sequences, the ex um which we note that the XOM refers to the coding regions only. And so knowing this and looking at the following answer choices, we could see that answer choice B says whole genome sequencing sequences, the entire genome while whole Xom sequencing sequences only the X um which we know is true and is the correct answer because whole genome sequencing includes both the coding and non coding regions, which is the entire genome. Whereas whole Xom sequencing only sequences the X um which is that coding region only. So answer choice B is the correct answer. I hope you found this video to be helpful. Thank you and goodbye.