Ch. 16 - Regulation of Gene Expression in Bacteria
Chapter 16, Problem 4
Contrast the role of the repressor in an inducible system and in a repressible system.
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Related Practice
Textbook Question
In this chapter, we focused on the regulation of gene expression in bacteria. Along the way, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter, what answers would you propose to the following fundamental questions?
How do we know that the trp operon is a repressible control system, in contrast to the lac operon, which is an inducible control system?
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Textbook Question
Write a brief essay that discusses why you think regulatory systems evolved in bacteria (i.e., what advantages do regulatory systems provide to these organisms?), and, in the context of regulation, discuss why genes related to common functions are found together in operons.
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Textbook Question
Contrast positive versus negative control of gene expression.
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Textbook Question
For the lac genotypes shown in the following table, predict whether the structural genes (Z) are constitutive, permanently repressed, or inducible in the presence of lactose.
Genotype Constitutive Repressed Inducible
I⁺O⁺Z⁺ x
I⁻O⁺Z⁺
I⁻OᶜZ⁺
I⁻OᶜZ⁺/F'O⁺
I⁺OᶜZ⁺/F'O⁺
IˢO⁺Z⁺
IˢO⁺Z⁺/F'I⁺
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Textbook Question
For the genotypes and conditions (lactose present or absent) shown in the following table, predict whether functional enzymes, nonfunctional enzymes, or no enzymes are made.
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Textbook Question
The locations of numerous lacI⁻ and lacIˢ mutations have been determined within the DNA sequence of the lacI gene. Among these, lacI⁻ mutations were found to occur in the 5′-upstream region of the gene, while lacIˢ mutations were found to occur farther downstream in the gene. Are the locations of the two types of mutations within the gene consistent with what is known about the function of the repressor that is the product of the lacI gene?
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