Ch. 14 - Translation and Proteins
Chapter 14, Problem 10
What are isoaccepting tRNAs? Assuming that there are only 20 different aminoacyl tRNA synthetases but 31 different tRNAs, speculate on parameters that might be used to ensure that each charged tRNA has received the correct amino acid.
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Textbook Question
Summarize the steps involved in charging tRNAs with their appropriate amino acids.
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Textbook Question
How many different proteins, each with a unique amino acid sequence, can be constructed that have a length of five amino acids?
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Textbook Question
To carry out its role, each transfer RNA requires at least four specific recognition sites that must be inherent in its tertiary structure. What are they?
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Textbook Question
When a codon in an mRNA with the sequence 5'-UAA-3' enters the A site of a ribosome, it is not recognized by a tRNA with a complementary anticodon. Why not? What recognizes it instead?
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Textbook Question
Predict the amino acid sequence produced during translation by the following short hypothetical mRNA sequences (note that the second sequence was formed from the first by a deletion of only one nucleotide):
Sequence 1: 5'-AUGCCGGAUUAUAGUUGA-3'
Sequence 2: 5'-AUGCCGGAUUAAGUUGA-3'
What type of mutation gave rise to sequence 2?
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Textbook Question
Discuss the potential difficulties of designing a diet to alleviate the symptoms of phenylketonuria.
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