At the end of the short arm of human chromosome 16 (16p), several genes associated with disease are present, including thalassemia and polycystic kidney disease. When that region of chromosome 16 was sequenced, gene-coding regions were found to be very close to the telomere-associated sequences. Could there be a possible link between the location of these genes and the presence of the telomere-associated sequences? What further information concerning the disease genes would be useful in your analysis?

Video transcript

Hello, everyone look at look at our next question. It says polycystic kidney disease. P. K. D. Is an autism, all dominant condition that affects both males and females equally. Which of the following is true. And when we look at our answer choices, we see that as well as our two choices A and B. Choice C. As A and B. So both of these being correct and choices none of the above. So neither of them being correct. So let's evaluate choices A. And B. First um Choice A says it is the most most frequent genetic cause of kidney failure in the pediatric age group. Well, this is not true. Um as it is not the most frequent cause of kidney failure in the pediatric age group. P K. D. Causes end stage renal disease in adults. The most common cause of kidney failure in Children is congenital abnormalities of the kidney or the urinary tract. So we already know A. Is not correct. So we know that A. And B. Choice C. Which is A. And B is also not our answer. So let's evaluate choice B. It says A. D. P. K. D. One genotype. So the A. D. Here just stands for autism will dominant. So it says A. D. P. K. D. One genotype is directly associated with an earlier onset of kidney failure. And as you can see by this name, there are actually two versions of P. K. D. Um both autism or dominant. Um P. K. D. One and A. D. P. K. D. Two and they are caused by mutations in two different genes. the PKB one gene and P K. D two gene. And it is true that PK. D one is a more um more severe form of the disease. It causes an earlier onset of end state renal disease um somewhere in the fifties, whereas a D P K. D to um causes a later onset Of end stage renal disease in the 70s. So choice BADPK. D one genotype is directly associated with an earlier onset of kidney failure. Is a is true. So we'll mark that and then we look at choice D. It's none of the above. So we can eliminate choice D since we have a correct answer here and since A is incorrect, our answer must be B. So again, um polycystic kidney disease and autism, a dominant condition that affects both males and females equally. Which is the following is true. Choice. B A. D P K. D one genotype is directly associated with an earlier onset of kidney failure. See you in the next video