How would you perform a genetic screen to identify genes directin...

Question

How would you perform a genetic screen to identify genes directing Drosophila wing development? Once you have a collection of wing-development mutants, how would you analyze your mutagenesis to learn how many genes are represented and how many alleles of each gene? How would you discover whether the genes act in the same or different pathways, and if in the same pathway, how do you discover the order in which they act? How would you clone the genes?

Accepted Answer

Hello, everyone and welcome to today's video. So what is the purpose of performing mu agenesis in a genetic screen for identifying genes involved in Drosophila wing development. As answer to A, we have to gene different wing phenotypes. As answer choice B, we have to create mutations in specific genes. As answer choice C we have to isolate metal lines with disrupted wing development genes. And as answer choice D we have to determine the order of gene action in wing development. Well, I want you to think about this for a second. When we are performing a genetic screen, we're analyzing the organism's genome. So we're going to get information on their genes and DNA sequences, but we're not really going to understand their function. So something that we could do is introduce neurogenesis. So we're going to introduce certain mutations or generate certain mutations in the organism genome. And then we're going to create these genetic screens that are going to allow us to understand their location of these mutations. Now, then we're going to analyze the phenotype of these organisms and if by any chance the the mutations cause some type of change to their wing development, then we know that these genes, the location of these genes is involved in your soul wing development. Now, because of this, the correct answer choice for this question is going to be the to determine the order of gene action in wing development. Now, the reason for this is that if we like we said, introduce these mutations in the in certain locations in the genome and then we screen them, then we're going to determine the gene or the order of gene action and wing development. As we're going to be able to analyze their phenotypes and see what corresponds with wing development. I really hope this helped you and I hope to see you on the next one.

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