In 2005, J. Robin Warren and Barry J. Marshall shared the Nobel Prize in Medicine for discovering the bacterium Helicobacter pylori and for establishing experimental proof that it plays a major role in gastritis and peptic ulcer disease. The story began when Warren, a pathologist, noticed that bacilli were associated with the tissues taken from patients suffering from ulcers. Look up the history of this case and describe Warren’s first hypothesis. What sorts of evidence were required to establish a credible theory based on it?

Verified step by step guidance

1. Step 1: Begin by researching the history of the discovery of Helicobacter pylori, focusing on the work of J. Robin Warren and Barry J. Marshall.
2. Step 2: Identify Warren's initial observations, particularly his hypothesis that the presence of bacilli (bacteria) was linked to gastric ulcers.
3. Step 3: Explore the types of evidence Warren and Marshall needed to gather to support their hypothesis, such as clinical studies, laboratory experiments, and patient case studies.
4. Step 4: Investigate how Warren and Marshall demonstrated the causative role of Helicobacter pylori in gastritis and peptic ulcer disease, including any experimental methods they used.
5. Step 5: Summarize the process by which their hypothesis was accepted by the scientific community, noting any challenges or breakthroughs that were pivotal in establishing a credible theory.