Chapter 46, Problem 9
Imagine a situation in which a morphogen has its source at the posterior end of a Drosophila embryo. Every 100 µm from the posterior pole, the morphogen concentration decreases by half. If a cell required 1/16th the amount of morphogen found at the posterior pole to form part of a leg, how far from the posterior pole would the leg form? a. 100 μm b. 160 μm c. 400 μm d. 1600 μm
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How do spermatogenesis and oogenesis in humans differ with respect to numbers of cells produced, gamete size, and timing of the second meiotic division?
Which of the following provides the strongest evidence for the conservation of tool-kit genes? a. Bicoid moved from one fly embryo into the posterior of another fly embryo causes the formation of two head regions. b. Mutation of an unrelated gene in another species of fly has a similar effect to mutation of bicoid in Drosophila. c. A mouse Hox gene can be used to take over the function of a mutated Drosophila Hox gene. d. Sheep can be cloned by fusing a differentiated adult cell with an enucleated egg.
Give examples of negative and positive feedback in hormonal control of the human menstrual cycle. Why can a high estradiol level be considered a 'readiness' signal from a follicle?
Propose an experiment to test the hypothesis that cells from only one region of a frog blastula form the ectoderm. What results from this experiment would support this hypothesis?
Some stickleback fish develop protective spines, and other stickleback fish are spineless. Spine development is controlled by the expression of a gene known as Pitx1. The spineless phenotype is due to a mutation in Pitx1 that results in no expression of Pitx1 during development in regions where spines would otherwise form. When scientists compared the Pitx1 coding sequence in spined and spineless fish, they found this sequence was the same in both types of fish. Propose plausible hypotheses for the location of this mutation and for how it alters spine development.
The BMI z-score is a relative measure of body mass index (BMI) that takes into account age. Higher values represent heavier individuals for a given height. The table here shows the BMI z-score of pre- and post-pubertal girls at three ages. Which of the following conclusions can you draw from the data? a. At a given age, there are more girls with low BMI z-scores than with high BMI z-scores. b. At a given age, girls with high BMI z-scores are more likely to have begun puberty than girls with low BMI z-scores. c. Girls 11, 12, and 13 years of age are equally likely to have begun puberty. d. There is no relationship between BMI z-score and age of beginning puberty.