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Ch. 18 - Regulation of Gene Expression
Chapter 18, Problem 6

What would occur if the repressor of an inducible operon were mutated so it could not bind the operator? a. irreversible binding of the repressor to the promoter b. reduced transcription of the operon's genes c. buildup of a substrate for the pathway controlled by the operon d. continuous transcription of the operon's genes

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Inducible Operon

An inducible operon is a type of genetic regulatory system that is typically off but can be activated in response to an inducer molecule. In this system, the presence of a specific substrate or signal leads to the inactivation of a repressor protein, allowing RNA polymerase to transcribe the genes necessary for metabolizing that substrate. This mechanism is crucial for the efficient use of resources by the cell.
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Inducible Operons

Repressor Protein

A repressor protein is a regulatory protein that binds to the operator region of an operon, blocking RNA polymerase from transcribing the downstream genes. In the case of an inducible operon, the repressor is usually bound to the operator until an inducer molecule is present, which causes a conformational change in the repressor, preventing it from binding to the operator and allowing gene expression to occur.
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Gene Transcription Regulation

Gene transcription regulation refers to the mechanisms that control the rate and timing of gene expression. In prokaryotes, this often involves operons, where the binding of repressors or activators to specific DNA sequences can either inhibit or promote transcription. Understanding these regulatory mechanisms is essential for predicting the effects of mutations, such as a repressor that cannot bind to the operator, which would lead to continuous transcription of the operon's genes.
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Introduction to Regulation of Gene Expression
Related Practice
Textbook Question

The functioning of enhancers is an example of a. a eukaryotic equivalent of prokaryotic promoter functioning. b. transcriptional control of gene expression. c. the stimulation of translation by initiation factors. d. post-translational control that activates certain proteins.

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Textbook Question

Cell differentiation always involves a. transcription of the myoD gene. b. the movement of cells. c. the production of tissue-specific proteins. d. the selective loss of certain genes from the genome.

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Textbook Question

Which of the following is an example of post-transcriptional control of gene expression? a. the addition of methyl groups to cytosine bases of DNA b. the binding of transcription factors to a promoter c. the removal of introns and alternative splicing of exons d. gene amplification contributing to cancer

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Textbook Question

Absence of bicoid mRNA from a Drosophila egg leads to the absence of anterior larval body parts and mirror-image duplication of posterior parts. This is evidence that the product of the bicoid gene a. normally leads to formation of head structures. b. normally leads to formation of tail structures. c. is transcribed in the early embryo. d. is a protein present in all head structures.

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Textbook Question

Which of the following statements about the DNA in one of your brain cells is true? a. Most of the DNA codes for protein. b. The majority of genes are likely to be transcribed. c. It is the same as the DNA in one of your liver cells. d. Each gene lies immediately adjacent to an enhancer.

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Textbook Question

Within a cell, the amount of protein made using a given mRNA molecule depends partly on a. the degree of DNA methylation. b. the rate at which the mRNA is degraded. c. the number of introns present in the mRNA. d. the types of ribosomes present in the cytoplasm.

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