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Ch. 26 Fluid, Electrolyte, and Acid-Base Balance
Chapter 25, Problem 14

Describe the thirst mechanism, indicating how it is triggered and terminated.

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The thirst mechanism is primarily regulated by the hypothalamus in the brain, which monitors the body's hydration status.
When the body experiences a decrease in blood volume or an increase in blood osmolality (concentration of solutes in the blood), osmoreceptors in the hypothalamus are activated.
These osmoreceptors stimulate the release of antidiuretic hormone (ADH) from the posterior pituitary gland, which helps the kidneys conserve water, and also trigger the sensation of thirst.
The sensation of thirst prompts an individual to drink fluids, which increases blood volume and decreases blood osmolality, thus restoring homeostasis.
Once the blood volume and osmolality return to normal levels, the osmoreceptors in the hypothalamus are no longer stimulated, leading to the termination of the thirst sensation.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Thirst Mechanism

The thirst mechanism is a physiological process that regulates fluid balance in the body. It is primarily controlled by the hypothalamus, which detects changes in blood osmolarity and volume. When the body becomes dehydrated, the hypothalamus triggers the sensation of thirst, prompting the individual to seek and consume water.
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Osmoreceptors

Osmoreceptors are specialized neurons located in the hypothalamus that monitor the osmotic pressure of the blood. When the concentration of solutes in the blood increases (indicating dehydration), these receptors activate the thirst response. Conversely, when hydration levels are restored, osmoreceptors signal the cessation of thirst, helping to maintain homeostasis.

Hormonal Regulation

Hormonal regulation plays a crucial role in the thirst mechanism, particularly through the action of hormones like antidiuretic hormone (ADH) and angiotensin II. ADH promotes water reabsorption in the kidneys, while angiotensin II stimulates thirst and increases blood pressure. Together, these hormones help to restore fluid balance and terminate the thirst response once hydration is achieved.
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