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Ch. 17 Blood
Chapter 16, Problem 2

Total peripheral resistance a. is inversely proportional to the length of the vascular bed, b. increases in anemia, c. decreases in polycythemia, d. is inversely related to the diameter of the arterioles.

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1
Understand the concept of Total Peripheral Resistance (TPR): TPR is the resistance to blood flow offered by all of the systemic vasculature, excluding the pulmonary vasculature.
Recall the factors affecting TPR: TPR is influenced by the diameter of blood vessels, blood viscosity, and the total length of the vascular system.
Analyze option a: Consider the relationship between TPR and the length of the vascular bed. Longer vascular beds increase resistance, not decrease it.
Analyze option b and c: Consider the effects of anemia and polycythemia on blood viscosity. Anemia decreases viscosity, potentially decreasing TPR, while polycythemia increases viscosity, potentially increasing TPR.
Analyze option d: Understand the relationship between TPR and the diameter of arterioles. TPR is inversely related to the fourth power of the radius of the arterioles, meaning smaller diameters significantly increase resistance.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Total Peripheral Resistance (TPR)

Total Peripheral Resistance refers to the overall resistance to blood flow in the systemic circulation. It is influenced by the diameter of blood vessels, blood viscosity, and the total length of the vascular system. TPR is a critical factor in determining blood pressure and is essential for understanding cardiovascular physiology.
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Vascular Bed Length

The length of the vascular bed is the total distance blood must travel through the circulatory system. According to the principles of hemodynamics, resistance is inversely proportional to the length of the vascular bed; longer vessels create more resistance, while shorter vessels allow for easier blood flow. This concept is vital for understanding how changes in vascular structure can affect blood pressure.
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Arteriolar Diameter

The diameter of arterioles plays a significant role in regulating blood flow and resistance. Wider arterioles decrease resistance, allowing for increased blood flow, while narrower arterioles increase resistance. This relationship is crucial for understanding how the body regulates blood pressure and distributes blood to various tissues during different physiological states.
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