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Ch. 17 Blood
Chapter 16, Problem 24

Cancer patients being treated with chemotherapeutic drugs designed to destroy rapidly dividing cells are monitored closely for changes in their red and white blood counts. Why so?

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1
Understand that chemotherapeutic drugs target rapidly dividing cells, which include cancer cells but also affect other rapidly dividing cells in the body.
Recognize that bone marrow is responsible for producing red blood cells (RBCs) and white blood cells (WBCs), and it contains rapidly dividing cells.
Acknowledge that chemotherapy can damage the bone marrow, leading to decreased production of RBCs and WBCs, causing conditions like anemia and leukopenia.
Realize that monitoring blood counts helps in assessing the impact of chemotherapy on the patient's bone marrow and overall health.
Consider that regular monitoring allows healthcare providers to adjust treatment plans to manage side effects and ensure patient safety.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Chemotherapy Mechanism

Chemotherapy drugs target rapidly dividing cells, a characteristic of cancer cells. However, these drugs are not selective and can also affect normal cells that divide quickly, such as those in the bone marrow, which produces red and white blood cells. This can lead to decreased blood cell counts, necessitating close monitoring.
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Hematopoiesis

Hematopoiesis is the process by which blood cells are produced in the bone marrow. It involves the differentiation of stem cells into various types of blood cells, including red blood cells (which carry oxygen) and white blood cells (which are crucial for immune response). Disruption of this process due to chemotherapy can lead to anemia and increased infection risk.
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Blood Cell Counts

Monitoring blood cell counts, specifically red blood cells (RBCs) and white blood cells (WBCs), is essential during chemotherapy. Low RBC counts can cause fatigue and weakness (anemia), while low WBC counts can increase the risk of infections (neutropenia). Regular blood tests help manage these risks and adjust treatment as necessary.
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