Principles of Human Physiology, 6th edition

Published by Pearson (January 5, 2016) © 2017

  • Cindy L. Stanfield University of South Alabama, Mobile, Alabama

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For courses in Human Physiology

Don’t just study–visualize, explore and solve problems in human physiology with Principles of Human Physiology!

Principles of Human Physiology, Sixth Edition uses a precise and clear-cut writing style to offer lasting comprehension for Human Physiology students, extending to real-life application in the field. The Sixth Edition provides essential digital resources to foster critical thinking and problem-solving skills. The exceptional art program is consistent, scientifically accurate, and visually appealing. Stanfield’s renowned flexible pedagogy allows instructors to choose what is essential to students when mapping out their course. 

MasteringA&P provides a framework for students to practice solving clinical problems, think conceptually, and apply new knowledge. Assigning interactive tutorials and coaching activities in MasteringA&P directs student learning on the toughest topics and provides a comprehensive and engaging learning environment.

Also available as a Pearson eText or packaged with Mastering A&P

Pearson eText is a simple-to-use, mobile-optimized, personalized reading experience that can be adopted on its own as the main course material. It lets students highlight, take notes, and review key vocabulary all in one place, even when offline. Seamlessly integrated videos and other rich media engage students and give them access to the help they need, when they need it. Educators can easily share their own notes with students so they see the connection between their eText and what they learn in class – motivating them to keep reading, and keep learning. Learn more about Pearson eText.


Mastering A&P is an online homework, tutorial, and assessment program designed to work with Principles of Human Physiology to engage students and improve results. Instructors ensure students arrive ready to learn by assigning educationally effective content before class, and encourage critical thinking and retention with in-class resources like Learning Catalyticsâ„¢. Students can further master concepts after class through traditional and adaptive homework assignments that provide hints and answer-specific feedback. With a wide range of activities available, students can actively learn, understand, and retain even the most difficult concepts.

Students, if interested in purchasing this title with MasteringA&P, ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information.

About the Book

  • NEW and UPDATED! The 6th Edition provides solutions to course challenges identified by multiple student focus groups and a panel of tech-savvy instructors, including a strong focus on supportive media and problem-solving in physiology.
  • NEW and UPDATED! Integrated icons cue students to exercises in Mastering A&P where they can make the most of Interpreting Data coaching activities, IP2.0, A&P Flix, and more! Excerpts from Solve It exercises appear in the end of select chapters and prompt students to dive deeper in Mastering A&P.
  • Special Feature boxes help instructors curate their specific course content and include:
    • Clinical Connections boxes focus on a range of topical issues to help students apply the physiology they learn to conditions such as cancer, cystic fibrosis, and hypertension.
    • Discovery boxes focus on current chapter-related topics in greater depth. Examples include coverage of antihistamines, vaults and chemotherapy, and neurogenesis.
    • Toolbox and Chemistry Review boxes review or introduce concepts from math, physics, and chemistry and show how they apply to physiology. By presenting this additional content in a way that complements the text, these boxes give instructors greater flexibility to tailor the material to students with a variety of backgrounds. Topic examples include the Nernst Equation, Fick’s Law, Laplace’s Law, and ions and ionic bonds.
    • Understanding Exercise boxes highlight a variety of exercise types and training levels to illustrate the application of physiological principles to numerous exercise scenarios.
  • Clear, pedagogically grounded art uses vibrant colors and graphics to support student learning. Selected figures in each chapter appear with key questions to reinforce learning.
  • Clinical content has been updated and expanded with more connections and applications of clinical material throughout the book, including:
    • Functional Facts and Health Facts are signaled with margin icons throughout the text to draw students’ attention to key applied content.
    • Focus on Diabetes boxes have been added throughout the text, making this key topic more prominent and accessible for readers. A capstone chapter on this disease reinforces the connectedness of the course material and encourages students to apply what they’ve learned to a real-world, significant problem.

Also available as a Pearson eText or packaged with Mastering A&P

Pearson eText is a simple-to-use, mobile-optimized, personalized reading experience that can be adopted on its own as the main course material. It lets students highlight, take notes, and review key vocabulary all in one place, even when offline. Seamlessly integrated videos and other rich media engage students and give them access to the help they need, when they need it. Educators can easily share their own notes with students so they see the connection between their eText and what they learn in class, motivating them to keep reading, and keep learning. Learn more about Pearson eText.

Mastering A&P is an online homework, tutorial, and assessment program designed to work with Principles of Human Physiology to engage students and improve results. Instructors ensure students arrive ready to learn by assigning educationally effective content before class, and encourage critical thinking and retention with in-class resources such as Learning Catalyticsâ„¢. Students can further master concepts after class through traditional and adaptive homework assignments that provide hints and answer-specific feedback. With a wide range of activities available, students can actively learn, understand, and retain even the most difficult concepts.

  • NEW! TEAS and HESI exam practice questions in the Study Area help students prep for the nursing school entrance exam with 150 TEAS and 300 HESI multiple-choice questions and wrong-answer feedback for all questions.
  • Practice Anatomy Lab (PAL) 4.0 is a virtual anatomy study and practice tool that provides students 24/7 access to the most widely used lab specimens including human cadaver, histology, cat, fetal pig, 3D and anatomical models. PAL 4.0 includes built-in audio pronunciations, mobile friendly flashcards, and multiple choice and fill-in-the blank lab practical quizzes. Questions with images from PAL can be assigned and automatically graded in the Mastering A&P Item Library.
  • NEW! Solve It tutorials engage students in a multi-step diagnosis in which they must analyze real data. Students begin by reading a clinical scenario and answering a question in the book, and then complete the tutorial through an assignable activity in Mastering A&P.
  • NEW! Interpreting Data tutorials coach students on how to interpret data from graphs and pie charts in the text. These tutorials are assignable in Mastering A&P.
  • NEW! Interactive Physiology 1.0 and 2.0 (IP 2.0) Coaching Activities help students dive deeper into complex physiological processes. Fun, interactive tutorials, games, and quizzes give students additional explanations to help them grasp difficult concepts. IP 2.0 features brand-new graphics, quicker navigation, and more robust interactivity, allowing students to explore, draw, predict, and gain a deep understanding of core physiological principles.
  • NEW! Nurses Need Physiology Case Studies are clinically relevant case studies designed as classroom activities, homework assignments, or peer-to-peer learning activities.
  • NEW! Dynamic Study Modules have been revised for this edition and are now organized into topic-specific modules.Dynamic Study Modules help students study effectively on their own by continuously assessing their activity and performance in real time. Here's how it works: students complete a set of questions with a unique answer format that also asks them to indicate their confidence level. Questions repeat until the student can answer them all correctly and confidently. Once completed, Dynamic Study Modules explain the concept using materials from the text. These are available as graded assignments prior to class or as self-study, and are accessible on smartphones, tablets, and computers.
  • NEW! Pearson eText features embedded media and reflowable content for flexible, comfortable reading experiences.
    • Now available on smartphones and tablets.
    • Seamlessly integrated videos and other rich media.
    • Accessible (screen-reader ready).
    • Configurable reading settings, including resizable type and night-reading mode.
    • Instructor and student note taking, highlighting, bookmarking, and search.
  • NEW! Learning Catalyticsâ„¢ is an interactive, classroom tool that uses students’ smartphones, tablets, or laptops to engage them in more sophisticated tasks and thinking. Now included with Mastering with eText, Learning Catalytics enables you to generate classroom discussion, guide your lecture, and promote peer-to-peer learning with real-time analytics. Instructors can:
    • Pose a variety of open-ended questions that help your students develop critical thinking skills
    • Monitor responses to find out where students are struggling
    • Use real-time data to adjust your instructional strategy and implement new means of engaging your students
    • Manage student interactions by automatically grouping students for discussion, teamwork, and peer-to-peer learning
  • Get Ready for A&P, 3rd Edition and MyReadinessTest quickly get students up to speed with basic study skills, math skills, anatomical terminology, basic chemistry, cell biology, and other basics of the human body.
    • With MyReadinessTest, students gain online access to a diagnostic test and personalized study plan that includes tutorials upon registration of their Human Physiology course.
    • The Get Ready for A&P workbook allows students to get up-to-speed as the course progresses. The 3rd Edition includes an online pre-test, guided explanations, interactive quizzes and exercises, and end-of-cumulative tests plus enhanced study tools and assessments in Mastering A&P and 10 Video Tutors that feature author Lori Garrett walking students through key basic concepts in chemistry and cell biology.
  • A&P Flixâ„¢ Coaching Activities offer stunning 3D visuals of core concepts and tough physiological concepts with in-depth assessments to test student understanding.
  • MicroFlixâ„¢ Coaching Activities present 3D animations of microbiology concepts related to A&P, like Immunology.
  • BioFlix® Coaching Activities bring difficult biology concepts related to A&P to life with dramatic three-dimensional representations of important processes and carefully developed step-by-step explanations: Meiosis, Cellular Respiration, Protein Synthesis, How Synapses Work, Homeostasis: Regulating Blood Sugar, and Gas Exchange.
  • PhysioExâ„¢ 9.1 and assessments.

About the Book

  • NEW and UPDATED! The 6th Edition provides solutions to course challenges identified by multiple student focus groups and a panel of tech-savvy instructors, including a strong focus on supportive media and problem-solving in physiology.
  • NEW and UPDATED! Integrated icons cue students to exercises in Mastering A&P where they can make the most of Interpreting Data coaching activities, IP2.0, A&P Flix, and more! Excerpts from Solve It exercises appear in the end of select chapters and prompt students to dive deeper in Mastering A&P.
  • Special Feature boxes help instructors curate their specific course content and include:
    • Clinical Connections boxes focus on a range of topical issues to help students apply the physiology they learn to conditions such as cancer, cystic fibrosis, and hypertension.
    • Discovery boxes focus on current chapter-related topics in greater depth. Examples include coverage of antihistamines, vaults and chemotherapy, and neurogenesis.
    • Toolbox and Chemistry Review boxes review or introduce concepts from math, physics, and chemistry and show how they apply to physiology. By presenting this additional content in a way that complements the text, these boxes give instructors greater flexibility to tailor the material to students with a variety of backgrounds. Topic examples include the Nernst Equation, Fick's Law, Laplace's Law, and ions and ionic bonds.
    • Understanding Exercise boxes highlight a variety of exercise types and training levels to illustrate the application of physiological principles to numerous exercise scenarios.
  • Clear, pedagogically grounded art uses vibrant colors and graphics to support student learning. Selected figures in each chapter appear with key questions to reinforce learning.
  • Clinical content has been updated and expanded with more connections and applications of clinical material throughout the book, including:
    • Functional Facts and Health Facts are signaled with margin icons throughout the text to draw students' attention to key applied content.
    • Focus on Diabetes boxes have been added throughout the text, making this key topic more prominent and accessible for readers. A capstone chapter on this disease reinforces the connectedness of the course material and encourages students to apply what they've learned to a real-world, significant problem.

Also available as a Pearson eText or packaged with Mastering A&P

Pearson eText is a simple-to-use, mobile-optimized, personalized reading experience that can be adopted on its own as the main course material. It lets students highlight, take notes, and review key vocabulary all in one place, even when offline. Seamlessly integrated videos and other rich media engage students and give them access to the help they need, when they need it. Educators can easily share their own notes with students so they see the connection between their eText and what they learn in class, motivating them to keep reading, and keep learning. Learn more about Pearson eText.

Mastering A&P is an online homework, tutorial, and assessment program designed to work with Principles of Human Physiology to engage students and improve results. Instructors ensure students arrive ready to learn by assigning educationally effective content before class, and encourage critical thinking and retention with in-class resources like Learning Catalyticsâ„¢. Students can further master concepts after class through traditional and adaptive homework assignments that provide hints and answer-specific feedback. With a wide range of activities available, students can actively learn, understand, and retain even the most difficult concepts.

  • TEAS and HESI exam practice questions in the Study Area help students prep for the nursing school entrance exam with 150 TEAS and 300 HESI multiple-choice questions and wrong-answer feedback for all questions.
  • Solve It tutorials engage students in a multi-step diagnosis in which they must analyze real data. Students begin by reading a clinical scenario and answering a question in the book, and then complete the tutorial through an assignable activity in Mastering A&P.
  • Interpreting Data tutorials coach students on how to interpret data from graphs and pie charts in the text. These tutorials are assignable in Mastering A&P.
  • Interactive Physiology 1.0 and 2.0 (IP 2.0) Coaching Activities help students dive deeper into complex physiological processes. Fun, interactive tutorials, games, and quizzes give students additional explanations to help them grasp difficult concepts. IP 2.0 features brand-new graphics, quicker navigation, and more robust interactivity, allowing students to explore, draw, predict, and gain a deep understanding of core physiological principles.
  • Nurses Need Physiology Case Studies are clinically relevant case studies designed as classroom activities, homework assignments, or peer-to-peer learning activities.
  • Dynamic Study Modules have been revised for this edition and are now organized into topic-specific modules.Dynamic Study Modules help students study effectively on their own by continuously assessing their activity and performance in real time. Here's how it works: students complete a set of questions with a unique answer format that also asks them to indicate their confidence level. Questions repeat until the student can answer them all correctly and confidently. Once completed, Dynamic Study Modules explain the concept using materials from the text. These are available as graded assignments prior to class or as self-study, and are accessible on smartphones, tablets, and computers.
  • Pearson eText features embedded media and reflowable content for flexible, comfortable reading experiences.
    • Now available on smartphones and tablets.
    • Seamlessly integrated videos and other rich media.
    • Accessible (screen-reader ready).
    • Configurable reading settings, including resizable type and night-reading mode.
    • Instructor and student note taking, highlighting, bookmarking, and search.
  • Learning Catalyticsâ„¢ is an interactive, classroom tool that uses students' smartphones, tablets, or laptops to engage them in more sophisticated tasks and thinking. Now included with Mastering with eText, Learning Catalytics enables you to generate classroom discussion, guide your lecture, and promote peer-to-peer learning with real-time analytics. Instructors can:
    • Pose a variety of open-ended questions that help your students develop critical thinking skills
    • Monitor responses to find out where students are struggling
    • Use real-time data to adjust your instructional strategy and implement new means of engaging your students
    • Manage student interactions by automatically grouping students for discussion, teamwork, and peer-to-peer learning

Brief Contents

  1. Introduction to Physiology
  2. The Cell: Structure and Function
  3. Cell Metabolism
  4. Cell Membrane Transport
  5. Chemical Messengers
  6. The Endocrine System: Endocrine Glands and Hormone Actions
  7. Nerve Cells and Electrical Signaling
  8. Synaptic Transmission and Neural Integration
  9. The Nervous System: Central Nervous System
  10. The Nervous System: Sensory Systems
  11. The Nervous System: Autonomic and Motor Systems
  12. Muscle Physiology
  13. The Cardiovascular System: Cardiac Function
  14. The Cardiovascular System: Blood Vessels, Blood Flow, and Blood Pressure
  15. The Cardiovascular System: Blood
  16. The Respiratory System: Pulmonary Ventilation
  17. The Respiratory System: Gas Exchange and the Regulation of Breathing
  18. The Urinary System: Renal Function
  19. The Urinary System: Fluid and Electrolyte Balance
  20. The Gastrointestinal System
  21. The Endocrine System. Regulation of Energy Metabolism and Growth
  22. The Reproductive System
  23. The Immune System
  24. Diabetes Mellitus

Cindy Stanfield earned her Ph.D in physiology at the University of California at Davis. She teaches human physiology lecture and laboratory courses and neuroscience at the University of South Alabama (USA), and researches sensory modulation. She received the College of Allied Health Professions Excellence in Service Award in 2003 and the University of South Alabama Excellence in Teaching Awards in 2004. She also serves as the advisor for the health pre-professionals at USA. She is a member of the Society for Neuroscience, the International Association for the Study of Pain, the American Pain Society, and the National Association of Advisors for the Health Professions.

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