Biomaterials: The Intersection of Biology and Materials Science, 1st edition
Published by Pearson (January 2, 2008) © 2009
- Johnna S. Temenoff Georgia Tech and Emory University
- Antonios G. Mikos
- Hardcover, paperback or looseleaf edition
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Co-authors, Johnna Temenoff and Antonios Mikos, are the 2010 Meriam/Wiley Distinguished Author Award Recipients for Biomaterials: The Intersection of Biology and Materials Science.
- Topics build from basic chemical/structural organisation of materials through physical and mechanical properties to material processing/manufacturing.
- Included at the end of each chapter are key measurement methods and techniques for determining/measuring the material or biological properties described.
- Each chapter includes a list of specific learning objectives.
Chapter 1: Materials for Biomedical Applications 1-1
1.1.   Introduction to biomaterials    1-2
1.2.  Biological response to biomaterials    1-8
1.3.  Biomaterial product testing and FDA approval    1-10
1.4.  Types of biomaterials      1-11
1.5.  Processing of biomaterials   1-15
1.6.  Important properties of biomaterials    1-16
1.7.  Principles of chemistry    1-21
1.8.  Summary    1-35
1.9.  Problems    1-37
1.10. Tables    1-39
1.11. Figures   1-44
1.12. References     1-70
1.13. Additional reading   1-72
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Chapter 2: Chemical Structure of Biomaterials     2-1
2.1.  Introduction: Bonding and the structure of biomaterials  2-2
2.2.  Structure of Metals     2-2
2.3.  Structure of Ceramics    2-18
2.4.  Structure of polymers      2-24
2.5.  Techniques: Introduction to material characterization     2-41
2.6.  Summary    2-62
2.7.  Problems    2-64
2.8.  Tables    2-69
2.9.  Figures   2-79
2.10. References     2-148
2.11. Additional reading   2-149
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Chapter 3: Physical Properties of Biomaterials  3-1
3.1.  Introduction: From atomic groupings to bulk materials   3-2
3.2.  Crystallinity and linear defects     3-2
3.3.  Crystallinity and planar defects    3-8
3.4.  Crystallinity and volume defects   3-12
3.5.  Crystallinity and polymeric materials    3-13
3.6.  Thermal transitions of crystalline and non-crystalline materials   3-18
3.7.  Techniques: Introduction to Thermal Analysis  3-26
3.8.  Summary    3-30
3.9.  Problems    3-32
3.10. Tables    3-35
3.11. Figures   3-38
3.12. References     3-63
3.13. Additional reading   3-64
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Chapter 4: Mechanical Properties of Biomaterials    4-1
4.1.  Introduction: Modes of mechanical testing   4-3
4.2.  Mechanical testing methods, results and calculations     4-3
4.3.  Fracture and failure     4-40
4.4.  Fatigue and fatigue testing   4-43
4.5.  Methods to improve mechanical properties  4-46
4.6.  Techniques: Introduction to Mechanical Analysis 4-49
4.7.  Summary    4-51
4.8.  Problems    4-54
4.9.  Figures   4-58
4.10. References     4-101
4.11. Additional reading   4-101
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Chapter 5: Biomaterial Degradation   5-1
5.1.  Introduction: Degradation in the biological environment     5-2
5.2.  Corrosion/degradation of metals and ceramics 5-3
5.3.  Degradation of polymers     5-18
5.4.  Biodegradable materials  5-22
5.5.  Techniques: Assays for extent of degradation   5-29
5.6.  Summary    5-30
5.7.  Problems    5-32
5.8.  Tables    5-37
5.9.  Figures   5-40
5.10. References     5-54
5.11. Additional reading   5-55
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Chapter 6: Biomaterial Processing  6-1
6.1.  Introduction: Importance of biomaterials processing     6-2
6.2.  Processing to improve bulk properties     6-2
6.3.  Processing to form desired shapes   6-12
6.4.  Processing to improve biocompatibility    6-26
6.5.  Summary    6-30
6.6.  Problems    6-32
6.7.  Tables    6-34
6.8.  Figures   6-35
6.9.  References     6-54
6.10. Additional reading   6-55
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Chapter 7: Surface Properties of Biomaterials   7-1
7.1.  Introduction: Concepts in surface chemistry and biology    7-2
7.2.  Physicochemical surface modification techniques  7-6
7.3.  Biological surface modification techniques    7-20
7.4.  Surface properties and degradation     7-25
7.5.  Patterning techniques for surfaces    7-25
7.6.  Techniques: Introduction to surface characterization 7-27
7.7.  Summary    7-46
7.8.  Problems    7-48
7.9.  Tables    7-53
7.10. Figures   7-58
7.11. References     7-107
7.12. Additional reading   7-109
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Chapter 8: Protein Interactions with Biomaterials 8-1
8.1.  Introduction: Thermodynamics of protein adsorption     8-2
8.2.  Protein structure     8-7
8.3.  Protein transport and adsorption kinetics 8-15
8.4.  Reversibility of protein adsorption   8-18
8.5.  Techniques: Assays for protein type and amount  8-22
8.6.  Summary    8-33
8.7.  Problems    8-35
8.8.  Tables    8-39
8.9.  Figures   8-42
8.10. References     8-74
8.11. Additional reading   8-75
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Chapter 9: Cell Interactions with Biomaterials   9-1
9.1.  Introduction: Cell-surface interactions and cellular functions   9-2
9.2.  Cellular structure     9-3
9.3.  Extracellular environment    9-14
9.4.  Cell-environment interactions affect cellular functions    9-23
9.5.  Models of adhesion, spreading and migration   9-34
9.6.  Techniques: Assays to determine effects of cell-material interactions 9-43
9.7.  Summary    9-53
9.8.  Problems    9-57
9.9.  Tables    9-61
9.10. Figures   9-62
9.11. References     9-113
9.12. Additional reading   9-115
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Chapter 10: Biomaterial Implantation and Acute Inflammation     10-1
10.1. Introduction: Overview of innate and acquired immunity    10-2
10.2. Clinical signs of inflammation and their causes  10-5
10.4. Role of other granulocytes   10-11
10.5. Termination of acute inflammation    10-16
10.6. Techniques: In vitro assays for inflammatory response   10-17
10.7. Summary    10-20
10.8. Problems    10-22
10.9. Tables    10-24
10.10.  Figures   10-27
10.11.  References     10-34
10.12.  Additional reading   10-34
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Chapter 11: Wound Healing and the Presence of Biomaterials  11-1
11.1. Introduction: Formation of granulation tissue     11-2
11.2. Foreign body reaction     11-3
11.3. Fibrous encapsulation     11-4
11.4. Chronic inflammation      11-7
11.5. Four types of resolution  11-8
11.6. Repair vs. regeneration: wound healing in skin  11-9
11.7. Techniques: In vivo assays for inflammatory response   11-12
11.8. Summary    11-20
11.9. Problems    11-22
11.10.  Tables    11-25
11.11.  Figures   11-28
11.12.  References     11-36
11.13.   Additional reading   11-37
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Chapter 12: Immune Response to Biomaterials     12-1
12.1. Introduction: Overview of acquired immunity   12-2
12.2. Antigen presentation and lymphocyte maturation  12-4
12.3. B cells and antibodies     12-8
12.4. T cells    12-12
12.5. The complement system  12-14
12.6. Undesired immune responses to biomaterials   12-19
12.7. Techniques: Assays for immune response    12-25
12.8. Summary    12-28
12.9. Problems    12-32
12.10.  Tables    12-34
12.11.  Figures   12-35
12.12.  References     12-51
12.13.  Additional reading   12-51
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Chapter 13: Biomaterials and Thrombosis  13-1
13.1. Introduction: Overview of hemostasis  13-2
13.2. Role of platelets      13-2
13.3. Coagulation cascade   13-5
13.4. Means of limiting clot formation   13-9
13.5. Role of endothelium    13-11
13.6. Tests for hemocompatibility     13-13
13.7. Summary    13-18
13.8. Problems    13-20
13.9. Tables    13-25
13.10.  Figures   13-27
13.11.  References     13-32
13.12.  Additional reading   13-33
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Chapter 14: Infection, Tumorigenesis and Calcification of Biomaterials  14-1
14.1.  Introduction: Overview of other potential problems with biomaterials implantation     14-2
14.2. Infection     14-2
14.3. Techniques for infection experiments   14-10
14.4. Tumorigenesis     14-16
14.5. Techniques for tumorigenesis experiments    14-21
14.6. Pathologic calcification    14-23
14.7. Techniques for pathologic calcification experiments   14-26
14.8. Summary    14-30
14.9. Problems    14-33
14.10.  Figures   14-36
14.11.  References     14-45
14.12.  Additional reading   14-46
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List of Abbreviations    Appendix I-1
List of Symbols     Appendix I-6
Index       Index
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