22. Carboxylic Acid Derivatives: NAS
Nucleophilic Acyl Substitution
5:49 minutes
Problem 24-45c
Textbook Question
Textbook QuestionThere are many methods for activating a carboxylic acid in preparation for coupling with an amine. The following method converts the acid to an N-hydroxysuccinimide (NHS) ester.
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(c) Propose a mechanism for the reaction of the NHS ester with an amine, R-NH2.
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