22. Carboxylic Acid Derivatives: NAS
Acid-Catalyzed Ester Hydrolysis
Problem 15f
Textbook Question
Textbook QuestionWhen a carboxylic acid is dissolved in isotopically labeled water (H2O18) and an acid catalyst is added, the label is incorporated into both oxygens of the acid. Propose a mechanism to account for this. CH3C=O(OH) + H2O HCl ⇌ + H2O If an ester is dissolved in isotopically labeled water (H2O18) and an acid catalyst is added, where will the label reside in the product?
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