22. Carboxylic Acid Derivatives: NAS
Nucleophilic Acyl Substitution
2:53 minutes
Problem 24-45a
Textbook Question
Textbook QuestionThere are many methods for activating a carboxylic acid in preparation for coupling with an amine. The following method converts the acid to an N-hydroxysuccinimide (NHS) ester.
<IMAGE of reaction>
(a) Explain why an NHS ester is much more reactive than a simple alkyl ester.
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