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Ch.25 Protein and Amino Acid Metabolism
Chapter 25, Problem 25.44

a. Name the four compounds within the citric acid cycle that the carbon skeletons of the glucogenic amino acid enter as.

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1
Identify the glucogenic amino acids, which are amino acids that can be converted into glucose through gluconeogenesis.
Understand that glucogenic amino acids are converted into intermediates of the citric acid cycle.
Recognize that the citric acid cycle, also known as the Krebs cycle, is a series of chemical reactions used by all aerobic organisms to generate energy.
Determine the specific intermediates of the citric acid cycle that glucogenic amino acids can be converted into.
List the four compounds within the citric acid cycle that serve as entry points for the carbon skeletons of glucogenic amino acids: oxaloacetate, α-ketoglutarate, succinyl-CoA, and fumarate.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Citric Acid Cycle

The citric acid cycle, also known as the Krebs cycle, is a key metabolic pathway that takes place in the mitochondria. It involves a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. Understanding this cycle is essential for identifying how glucogenic amino acids contribute to energy production.
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Glucogenic Amino Acids

Glucogenic amino acids are those that can be converted into glucose through gluconeogenesis. They enter metabolic pathways that lead to the production of glucose, particularly during periods of fasting or intense exercise. Recognizing which amino acids are glucogenic helps in understanding their role in the citric acid cycle and energy metabolism.
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Carbon Skeletons

The carbon skeleton of an amino acid refers to the carbon chain that remains after the amino group is removed. This skeleton can be converted into various intermediates that enter the citric acid cycle. Identifying the specific carbon skeletons of glucogenic amino acids is crucial for determining how they integrate into the cycle and contribute to energy production.
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