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Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination
Chapter 11, Problem 5

In March 2011 an earthquake measuring approximately 9.0 on the Richter scale struck Fukushima, Japan. Several nuclear reactors at the Fukushima Daichii Nuclear Power Plant were damaged, and nuclear core meltdown occurred. A massive release of radiation accompanied damage to the plant, and 5 years later the incidence of thyroid cancer in children exposed to the radiation was determined to be well over 100 times more frequent than expected without radiation exposure. DNA damage and mutations resulting from radiation exposure are suspected of causing this increased cancer rate. Do you think it is possible that significant increases in the incidence of other types of cancer will occur in the future among people who were exposed to the Fukushima radiation? Why?

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1
Understand that radiation exposure can cause DNA damage, leading to mutations.
Recognize that mutations in certain genes can lead to cancer if they affect cell growth and division.
Consider that different types of cells and tissues have varying sensitivities to radiation, which can influence cancer risk.
Acknowledge that the latency period for different cancers can vary, meaning some may take years or decades to develop after exposure.
Evaluate the potential for increased cancer incidence by considering factors such as the level of exposure, the population's genetic predisposition, and ongoing monitoring and research findings.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Radiation and DNA Damage

Radiation can cause direct damage to DNA molecules, leading to mutations. This damage can disrupt normal cellular functions and potentially initiate cancerous growth. The severity of the damage often depends on the type and dose of radiation exposure, with higher doses increasing the likelihood of significant genetic alterations.
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Cancer Risk and Epidemiology

Epidemiology studies the distribution and determinants of health-related states, including cancer. Increased cancer incidence in populations exposed to radiation can be assessed through epidemiological studies, which compare cancer rates in exposed groups to those in unexposed groups. Understanding these patterns helps predict future cancer risks.
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Latency Period of Cancer

Cancer often has a latency period, which is the time between exposure to a carcinogen and the development of cancer. This period can vary significantly depending on the type of cancer and the individual’s genetic predisposition. For radiation-induced cancers, this latency can range from several years to decades, suggesting that increased cancer rates may emerge long after initial exposure.
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Related Practice
Textbook Question

Explain the following processes involving chromosome mutations and cancer development.

How the chromosome mutation producing the Philadelphia chromosome leads to CML.

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Textbook Question
Explain the following processes involving chromosome mutations and cancer development. How the chromosome mutation producing Burkitt lymphoma generates the disease.
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Textbook Question
In March 2011 an earthquake measuring approximately 9.0 on the Richter scale struck Fukushima, Japan. Several nuclear reactors at the Fukushima Daichii Nuclear Power Plant were damaged, and nuclear core meltdown occurred. A massive release of radiation accompanied damage to the plant, and 5 years later the incidence of thyroid cancer in children exposed to the radiation was determined to be well over 100 times more frequent than expected without radiation exposure. DNA damage and mutations resulting from radiation exposure are suspected of causing this increased cancer rate. What gene discussed in this chapter might be responsible for pausing the cell cycle of dividing cells long enough for radiation-induced damage to be repaired in cells?
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Textbook Question

UV irradiation causes damage to bacterial DNA. What kind of damage is frequently caused and how does photolyase repair the damage?

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Textbook Question

Ultraviolet (UV) radiation is mutagenic.

How do UV-induced DNA lesions lead to mutation?

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Textbook Question

Ultraviolet (UV) radiation is mutagenic.

Identify and describe two DNA repair mechanisms that remove UV-induced DNA lesions.

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