Textbook Question
Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
p53 (Li–Fraumeni syndrome)
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Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination
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Sanders 3rd EditionCh. 11 - Gene Mutation, DNA Repair, and Homologous RecombinationProblem 1
Sanders 3rd EditionCh. 11 - Gene Mutation, DNA Repair, and Homologous RecombinationProblem 1Chapter 11, Problem 1
Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
c-MYC (Burkitt lymphoma)
Verified step by step guidance1
Understand that c-MYC is a proto-oncogene, which means it normally plays a role in cell growth and division.
Recognize that proto-oncogenes like c-MYC are crucial for normal cellular functions, such as promoting cell cycle progression and proliferation.
Learn that in Burkitt lymphoma, a chromosomal translocation often occurs, leading to the overexpression of the c-MYC gene.
This overexpression results in uncontrolled cell proliferation, contributing to the development of cancer.
Remember that the normal function of c-MYC is to regulate genes involved in cell growth, metabolism, and apoptosis, maintaining a balance in cell proliferation.
Verified Solution
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
c-MYC Gene Function
The c-MYC gene is a proto-oncogene that encodes a transcription factor involved in cell cycle regulation, apoptosis, and cellular growth. It plays a crucial role in promoting cell proliferation and is essential for normal cellular functions. When mutated or overexpressed, c-MYC can lead to uncontrolled cell division, contributing to cancer development, such as in Burkitt lymphoma.
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Functional Genomics
Proto-oncogenes and Oncogenes
Proto-oncogenes are normal genes that, when mutated or abnormally expressed, can become oncogenes, leading to cancer. They typically promote cell growth and division. Understanding the transition from proto-oncogene to oncogene is vital in cancer biology, as it highlights how genetic alterations can disrupt normal cellular processes and lead to malignancies.
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Burkitt Lymphoma
Burkitt lymphoma is a type of non-Hodgkin lymphoma characterized by the rapid growth of tumors, often associated with the c-MYC gene's translocation. This cancer is linked to the overexpression of c-MYC due to chromosomal rearrangements, which leads to increased cell proliferation. Recognizing the relationship between c-MYC mutations and Burkitt lymphoma is essential for understanding the genetic basis of this cancer.
Related Practice
Textbook Question
Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
Which of these genes would you classify as a proto-oncogene and which as a tumor suppressor gene? Explain your categorization for each gene.
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Textbook Question
Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
APC (familial adenomatous polyposis)
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Textbook Question
Identify two general ways chemical mutagens can alter DNA. Give examples of these two mechanisms.
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Textbook Question
Go online to the Online Mendelian Inheritance of Man (OMIM) website. Look up the following genetic conditions and answer the questions posed about them.
Look up Tay–Sachs disease (TSD), OMIM number 272800, and give the name and abbreviation of the affected gene and the chromosome location of the gene.
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Textbook Question
Go online to the Online Mendelian Inheritance of Man (OMIM) website. Look up the following genetic conditions and answer the questions posed about them.
Go to the 'Population Genetics' section discussing the TSD gene. In a few sentences, summarize the human population in which TSD is most frequently found and give the approximate frequency of heterozygous carriers for the TSD mutation in North American Jews.
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