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Ch. 4 - Extensions of Mendelian Genetics
Chapter 4, Problem 27

In Drosophila, the X-linked recessive mutation vermilion (v) causes bright red eyes, in contrast to the brick-red eyes of wild type. A separate autosomal recessive mutation, suppressor of vermilion (su-v), causes flies homozygous or hemizygous for v to have wild-type eyes. In the absence of vermilion alleles, su-v has no effect on eye color. Determine the F₁ and F₂ phenotypic ratios from a cross between a female with wild-type alleles at the vermilion locus, but who is homozygous for su-v, with a vermilion male who has wild-type alleles at the su-v locus.

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Identify the genotypes of the parents: The female is wild-type at the vermilion locus (V) and homozygous for the suppressor (su-v/su-v), while the male is vermilion (v) and wild-type at the suppressor locus (Su-v/Su-v).
Determine the gametes produced by each parent: The female can produce gametes with V, su-v, and the male can produce gametes with v, Su-v.
Perform the F₁ cross: Combine the gametes from each parent to determine the F₁ genotypes. The female's gametes (V, su-v) will combine with the male's gametes (v, Su-v).
Analyze the F₁ phenotypes: Since the vermilion mutation is X-linked, consider the sex of the offspring. The presence of the suppressor (su-v) in homozygous form will affect the vermilion phenotype.
Perform the F₂ cross: Cross the F₁ individuals to determine the F₂ genotypes and phenotypes. Consider the segregation of both the X-linked vermilion and the autosomal suppressor alleles.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

X-linked Inheritance

X-linked inheritance refers to the pattern of genetic transmission of traits located on the X chromosome. In Drosophila, males have one X chromosome and one Y chromosome, while females have two X chromosomes. This means that X-linked recessive traits, like the vermilion mutation, are more likely to be expressed in males, as they only need one copy of the recessive allele to show the trait.
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Autosomal Recessive Inheritance

Autosomal recessive inheritance involves genes located on non-sex chromosomes (autosomes) where two copies of a recessive allele are required for the phenotype to be expressed. In this case, the suppressor of vermilion (su-v) is an autosomal recessive mutation that can mask the effects of the vermilion mutation when present in a homozygous or hemizygous state, demonstrating the interaction between different genetic loci.
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Phenotypic Ratios in Genetic Crosses

Phenotypic ratios describe the relative frequencies of different observable traits in the offspring resulting from a genetic cross. In this scenario, understanding how to set up a Punnett square for the cross between the wild-type female (homozygous for su-v) and the vermilion male will help determine the expected ratios of eye color phenotypes in the F₁ and F₂ generations, illustrating the principles of inheritance and gene interaction.
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Related Practice
Textbook Question
In humans, the ABO blood type is under the control of autosomal multiple alleles. Color blindness is a recessive X-linked trait. If two parents who are both type A and have normal vision produce a son who is color-blind and is type O, what is the probability that their next child will be a female who has normal vision and is type O?
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Textbook Question
In Drosophila, an X-linked recessive mutation, scalloped (sd), causes irregular wing margins. Diagram the F₁ and F₂ results if (a) a scalloped female is crossed with a normal male; (b) a scalloped male is crossed with a normal female. Compare these results with those that would be obtained if the scalloped gene were autosomal.
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Textbook Question
In mice, the X-linked dominant mutation Testicular feminization (Tfm) eliminates the normal response to the testicular hormone testosterone during sexual differentiation. An XY mouse bearing the Tfm allele on the X chromosome develops testes, but no further male differentiation occurs—the external genitalia of such an animal are female. From this information, what might you conclude about the role of the Tfm gene product and the X and Y chromosomes in sex determination and sexual differentiation in mammals? Can you devise an experiment, assuming you can 'genetically engineer' the chromosomes of mice, to test and confirm your explanation?
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Textbook Question
When the cloned cat Carbon Copy (CC) was born (see the Now Solve This question in Section 7.4), she had black patches and white patches, but completely lacked any orange patches. The knowledgeable students of genetics were not surprised at this outcome. Starting with the somatic ovarian cell used as the source of the nucleus in the cloning process, explain how this outcome occurred.
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Textbook Question
While vermilion is X-linked in Drosophila and causes the eye color to be bright red, brown is an autosomal recessive mutation that causes the eye to be brown. Flies carrying both mutations lose all pigmentation and are white-eyed. Predict the F₁ and F₂ results of the following crosses: vermilion females x brown males
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Textbook Question
While vermilion is X-linked in Drosophila and causes the eye color to be bright red, brown is an autosomal recessive mutation that causes the eye to be brown. Flies carrying both mutations lose all pigmentation and are white-eyed. Predict the F₁ and F₂ results of the following crosses: brown females x vermilion males
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