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Ch. 20 - Recombinant DNA Technology
Chapter 19, Problem 8

Might it make sense someday to sequence every newborn's genome at the time of birth? What are the potential advantages and concerns of this approach?

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span>Step 1: Understand the concept of genome sequencing. Genome sequencing is the process of determining the complete DNA sequence of an organism's genome at a single time. It involves identifying the order of the four chemical building blocks - adenine (A), cytosine (C), guanine (G), and thymine (T) - that make up the DNA molecule.</span
span>Step 2: Consider the potential advantages of sequencing every newborn's genome. This could include early detection of genetic disorders, personalized medicine, and better understanding of an individual's health risks, which could lead to preventive measures and tailored healthcare plans.</span
span>Step 3: Reflect on the ethical, legal, and social concerns. These might involve privacy issues, potential discrimination based on genetic information, and the psychological impact of knowing one's genetic predispositions from birth.</span
span>Step 4: Evaluate the technological and economic feasibility. Consider the current cost and accessibility of genome sequencing technology, and whether it is practical to implement on a large scale for every newborn.</span
span>Step 5: Discuss the implications for healthcare systems and policy. This includes how healthcare providers might need to adapt to integrate genetic information into routine care, and the potential need for new regulations to protect individuals' genetic data.</span

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Genomic Sequencing

Genomic sequencing is the process of determining the complete DNA sequence of an organism's genome. This technology allows for the identification of genetic variations that can influence health, disease susceptibility, and response to treatments. In the context of newborns, sequencing can provide critical information for early diagnosis and personalized medicine.
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Ethical Considerations

The ethical considerations surrounding genomic sequencing of newborns include issues of consent, privacy, and potential discrimination. Parents may not fully understand the implications of having their child's genome sequenced, and there are concerns about how this sensitive information could be used by employers or insurance companies. Balancing the benefits of early detection with these ethical dilemmas is crucial.
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Public Health Implications

The public health implications of sequencing every newborn's genome involve the potential for improved health outcomes through early intervention and preventive care. By identifying genetic predispositions to certain conditions, healthcare providers can tailor monitoring and treatment strategies. However, this approach also raises questions about resource allocation and the capacity of healthcare systems to manage the resulting data.
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Related Practice
Textbook Question

Using DNA sequencing on a cloned DNA segment, you recover the nucleotide sequence shown below. Does this segment contain a palindromic recognition sequence for a restriction enzyme? If so, what is the double-stranded sequence of the palindrome, and what enzyme would cut at this sequence? (Consult Figure 20.1 for a list of restriction sites.)

CAGTATGGATCCCAT

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Textbook Question

As genetic testing becomes widespread, medical records will contain the results of such testing. Who should have access to this information? Should employers, potential employers, or insurance companies be allowed to have this information? Would you favor or oppose having the government establish and maintain a central database containing the results of individuals' genome scans?

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Textbook Question

Restriction sites are palindromic; that is, they read the same in the 5' to 3' direction on each strand of DNA. What is the advantage of having restriction sites organized this way?

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Textbook Question

List the advantages and disadvantages of using plasmids as cloning vectors. What advantages do BACs and YACs provide over plasmids as cloning vectors?

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Textbook Question

Which of the examples of genetic testing below are prognostic tests? Which are diagnostic?

Genetic testing in a healthy teenager identifies an SNP correlated with autism.

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Textbook Question

Which of the examples of genetic testing below are prognostic tests? Which are diagnostic?

An adult diagnosed with Asperger syndrome (AS) has a genetic test that reveals a SNP in the GABRB3 gene that is significantly more common in people with AS than the general population.

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