Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
11. Translation
Translation
Problem 39d
Textbook Question
Answer the following questions about the accompanying diagram.

Indicate where fMet is located in the string to the right of G.

1
Identify the components in the diagram: A is DNA, B is RNA polymerase, C is mRNA, D is ribosome, E is tRNA, F is polypeptide chain, and G is the start codon region.
Understand that fMet (formylmethionine) is the first amino acid incorporated during the initiation of protein synthesis in prokaryotes.
Locate the start codon (AUG) on the mRNA strand, which is typically the first codon translated by the ribosome.
Recognize that the tRNA carrying fMet will bind to the start codon (AUG) on the mRNA at the ribosome site labeled G.
Conclude that fMet is located at the position where the tRNA labeled E is bound to the mRNA at the start codon near G.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Translation in Genetics
Translation is the process by which ribosomes synthesize proteins using messenger RNA (mRNA) as a template. During translation, the ribosome reads the mRNA sequence in sets of three nucleotides, known as codons, each of which corresponds to a specific amino acid. This process is crucial for gene expression and the production of proteins that perform various functions in the cell.
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Translation initiation
Start Codon and fMet
The start codon, typically AUG, signals the beginning of translation and codes for the amino acid methionine, which is often modified to form N-formylmethionine (fMet) in prokaryotes. fMet is important for initiating protein synthesis in bacteria and is recognized by the ribosome as the first amino acid in the growing polypeptide chain. Its location in the mRNA sequence is critical for proper translation initiation.
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Translation initiation
Amino Acid Sequence
The amino acid sequence of a protein is determined by the sequence of codons in the mRNA. Each codon corresponds to a specific amino acid, and the order of these codons dictates the structure and function of the resulting protein. Understanding the relationship between the mRNA sequence and the amino acid sequence is essential for interpreting diagrams related to translation and protein synthesis.
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Sequencing Difficulties
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