Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
19. Cancer Genetics
Cancer Mutations
2:45 minutes
Problem 11
Textbook Question
Textbook QuestionPart of the Ras protein is associated with the plasma membrane, and part extends into the cytoplasm. How does the Ras protein transmit a signal from outside the cell into the cytoplasm? What happens in cases where the ras gene is mutated?
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Signal Transduction
Signal transduction is the process by which a cell responds to external signals, often involving a series of molecular events. In the case of the Ras protein, it acts as a molecular switch that relays signals from cell surface receptors to intracellular pathways, facilitating communication between the extracellular environment and the cytoplasm.
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Transduction
Ras Protein Function
The Ras protein is a small GTPase that plays a critical role in cell signaling pathways, particularly those regulating cell growth and differentiation. When activated by binding to GTP, Ras interacts with various downstream effectors, propagating the signal within the cell. This activation is crucial for normal cellular functions.
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Proteins
Mutations in the Ras Gene
Mutations in the ras gene can lead to constitutive activation of the Ras protein, meaning it remains in an active state regardless of external signals. This can result in uncontrolled cell proliferation and is commonly associated with various cancers. Understanding these mutations is essential for developing targeted therapies in cancer treatment.
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Cancer Mutations
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