Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
2. Mendel's Laws of Inheritance
Dihybrid Cross
Problem 17b
Textbook Question
In rats, the following genotypes of two independently assorting autosomal genes determine coat color: A— B— (gray) A — bb. (yellow) aaB— (black) aabb (cream) A third gene pair on a separate autosome determines whether or not any color will be produced. The CC and Cc genotypes allow color according to the expression of the A and B alleles. However, the cc genotype results in albino rats regardless of the A and B alleles present. Determine the F₁ phenotypic ratio of the following crosses: AaBBCc×AaBBCc
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1
Identify the genotypes involved in the cross: AaBBCc × AaBBCc.
Determine the possible gametes each parent can produce. For AaBBCc, the possible gametes are ABC, ABc, aBC, and aBc.
Use a Punnett square to combine the gametes from both parents and determine the genotypic combinations of the offspring.
Identify the phenotypes based on the genotypes. Remember that cc results in albino, regardless of other alleles, and CC or Cc allows expression of A and B alleles.
Count the number of offspring for each phenotype to determine the phenotypic ratio.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Independent Assortment
Independent assortment is a fundamental principle of genetics stating that alleles for different genes segregate independently of one another during gamete formation. This means that the inheritance of one trait will not affect the inheritance of another, allowing for a variety of combinations in offspring. Understanding this concept is crucial for predicting the phenotypic ratios resulting from genetic crosses.
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Genotype and Phenotype
The genotype refers to the genetic makeup of an organism, specifically the alleles present for a given trait, while the phenotype is the observable expression of those traits. In this question, the genotypes of the rats determine their coat color, which is the phenotype. Recognizing the relationship between genotype and phenotype is essential for determining the expected outcomes of genetic crosses.
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Epistasis
Epistasis occurs when the expression of one gene is affected by one or more other genes, leading to interactions that can mask or modify phenotypic expression. In this scenario, the presence of the cc genotype inhibits color production regardless of the A and B alleles, demonstrating epistatic effects. Understanding epistasis is vital for accurately predicting phenotypic ratios in complex genetic crosses.
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